HTLV-1 Infection and Neuropathogenesis in the Context of Rag1-/-γc-/- (RAG1-Hu) and BLT Mice

R Ginwala, B Caruso, ZK Khan, A Pattekar… - Journal of Neuroimmune …, 2017 - Springer
To date, the lack of a suitable small animal model has hindered our understanding of
Human T-cell lymphotropic virus (HTLV)-1 chronic infection and associated …

[HTML][HTML] HAM/TSP-derived HTLV-1-infected T cell lines promote morphological and functional changes in human astrocytes cell lines: possible role in the enhanced T …

ES Gudo, SD Silva-Barbosa, L Linhares-Lacerda… - Virology Journal, 2015 - Springer
Background The mechanisms through which HTLV-1 leads to and maintains damage in the
central nervous system of patients undergoing HTLV-1 associated myelopathy/tropical …

[HTML][HTML] Human T-lymphotropic virus type 1 (HTLV-1) and cellular immune response in HTLV-1-associated myelopathy/tropical spastic paraparesis

S Nozuma, R Kubota, S Jacobson - Journal of NeuroVirology, 2020 - Springer
Human T-lymphotropic virus type 1 (HTLV-1) is associated with adult T cell
leukemia/lymphoma and HTLV-1-associated myelopathy/tropical spastic paraparesis …

[HTML][HTML] Abnormally High Levels of Virus-Infected IFN-γ+CCR4+CD4+CD25+ T Cells in a Retrovirus-Associated Neuroinflammatory Disorder

Y Yamano, N Araya, T Sato, A Utsunomiya, K Azakami… - PloS one, 2009 - journals.plos.org
Background Human T-lymphotropic virus type 1 (HTLV-1) is a human retrovirus associated
with both HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), which is a …

Novel insights into human T‐lymphotropic virus type‐1 (HTLV‐1) pathogenesis‐host interactions in the manifestation of HTLV‐1‐associated myelopathy/tropical …

S Ahmadi Ghezeldasht, A Mosavat… - Reviews in Medical …, 2024 - Wiley Online Library
Human T‐lymphotropic virus type‐1 (HTLV‐1) was the first discovered human oncogenic
retrovirus, the etiological agent of two serious diseases have been identified as adult T‐cell …

A new hypothesis for the pathogenesis of Human T-lymphotropic virus type 1 associated myelopathy/tropical spastic paraparesis

AJ Mosley, CRM Bangham - Bioscience Hypotheses, 2009 - Elsevier
The exogenous, human retrovirus Human T-lymphotropic virus type 1 (HTLV-1) results in a
highly dynamic persistent infection. HTLV-1 usually causes an asymptomatic infection but a …

Human T-lymphotropic virus type 1 (HTLV-1) and regulatory T cells in HTLV-1-associated neuroinflammatory disease

N Araya, T Sato, N Yagishita, H Ando, A Utsunomiya… - Viruses, 2011 - mdpi.com
Human T-lymphotropic virus type 1 (HTLV-1) is a retrovirus that is the causative agent of
adult T cell leukemia/lymphoma (ATL) and associated with multiorgan inflammatory …

HTLV-1 induces a Th1-like state in CD4+ CCR4+ T cells that produces an inflammatory positive feedback loop via astrocytes in HAM/TSP

Y Yamano, A Coler-Reilly - Journal of neuroimmunology, 2017 - Elsevier
The main feature of Human T-lymphotropic virus type I (HTLV-1)-associated
myelopathy/tropical spastic paraparesis (HAM/TSP) pathogenesis is a virus-induced …

Visualization of HTLV-1–specific cytotoxic T lymphocytes in the spinal cords of patients with HTLV-1–associated myelopathy/tropical spastic Paraparesis

E Matsuura, R Kubota, Y Tanaka… - … of Neuropathology & …, 2015 - academic.oup.com
Activated human T-lymphotropic virus type-1 (HTLV-1)–specific CD8-positive cytotoxic T
lymphocytes (CTLs) are markedly increased in the periphery of patients with HTLV-1 …

[HTML][HTML] Cytokine networks dysregulation during HTLV-1 infection and associated diseases

N Futsch, G Prates, R Mahieux, J Casseb, H Dutartre - Viruses, 2018 - mdpi.com
Human T-cell leukemia virus type 1 (HTLV-1) is the causative agent of a neural chronic
inflammation, called HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) …