Cellular senescence is an antiproliferative response with a critical role in the control of
cellular balance in diverse physiological and pathological settings. Here, we set to study the …

Idiopathic pulmonary fibrosis (IPF) is a fatal age-associated disease with no cure. Although
IPF is widely regarded as a disease of aging, the cellular mechanisms that contribute to this …

The discovery of the myofibroblast has opened new perspectives for the comprehension of
the biological mechanisms involved in wound healing and fibrotic diseases. In recent years …

Organ fibrosis is a lethal outcome of autoimmune rheumatic diseases such as systemic
sclerosis. Myofibroblasts are scar-forming cells that are ultimately responsible for the …

Myofibroblasts are characterized by their expression of α-smooth muscle actin, their
enhanced contractility when compared to normal fibroblasts and their increased synthetic …

Myofibroblasts are key cells in mediating normal wound contraction and promoting
connective tissue deformations characteristic of fibrosis and scarring. Five decades ago …

Tissue-resident fibroblasts are mesenchymal cells which control the structural integrity of the
extracellular matrix (ECM). Fibroblasts possess a remarkable plasticity to allow them to …

Cancer-associated fibroblasts (CAF) remain a poorly characterized, heterogeneous cell
population. Here we characterized two previously described tumor-promoting CAF sub …

Tissue-resident fibroblasts are mesenchymal cells which possess an impressive plasticity in
their ability to modify their properties according to the requirements of the microenvironment …

• Introduction• The evolving definition of the myofibroblast: promoting an understanding of
biology and pathology•‐From early ultrastructural criteria to a comprehensive definition• …