[HTML][HTML] Crossed pathways for radiation-induced and immunotherapy-related lung injury

Z Zhang, J Zhou, V Verma, X Liu, M Wu, J Yu… - Frontiers in …, 2021 - frontiersin.org
Radiation-induced lung injury (RILI) is a form of radiation damage to normal lung tissue
caused by radiotherapy (RT) for thoracic cancers, which is most commonly comprised of …

[HTML][HTML] Radiation-induced lung injury (RILI)

L Giuranno, J Ient, D De Ruysscher, MA Vooijs - Frontiers in oncology, 2019 - frontiersin.org
Radiation pneumonitis (RP) and radiation fibrosis (RF) are two dose-limiting toxicities of
radiotherapy (RT), especially for lung, and esophageal cancer. It occurs in 5–20% of …

[HTML][HTML] Promising biomarkers of radiation-induced lung injury: a review

X Liu, C Shao, J Fu - Biomedicines, 2021 - mdpi.com
Radiation-induced lung injury (RILI) is one of the main dose-limiting side effects in patients
with thoracic cancer during radiotherapy. No reliable predictors or accurate risk models are …

[HTML][HTML] Exploration of radiation-induced lung injury, from mechanism to treatment: a narrative review

Y Yan, J Fu, RO Kowalchuk, CM Wright… - … lung cancer research, 2022 - ncbi.nlm.nih.gov
Methods PubMed was used to collect articles about RILI from 1995 to 2021. The papers
included clinical trials, reviews, as well as systematic reviews and meta-analyses. Based on …

[HTML][HTML] ACT001 Ameliorates ionizing radiation-induced lung injury by inhibiting NLRP3 inflammasome pathway

H Luo, X Liu, H Liu, Y Wang, K Xu, J Li, M Liu… - Biomedicine & …, 2023 - Elsevier
Radiotherapy is a prevalent treatment modality for thoracic tumors; however, it can lead to
radiation-induced lung injury (RILI), which currently lacks effective interventions. ACT001, a …

[HTML][HTML] Pulmonary toxicity generated from radiotherapeutic treatment of thoracic malignancies

G Deng, N Liang, J Xie, H Luo, L Qiao… - Oncology …, 2017 - spandidos-publications.com
Radiation-induced lung injury (RILI) remains a major obstacle for thoracic radiotherapy for
the treatment of lung cancer, esophageal cancer and lymphoma. It is the principal dose …

[HTML][HTML] Radiation-induced lung toxicity–cellular and molecular mechanisms of pathogenesis, management, and literature review

L Käsmann, A Dietrich, CA Staab-Weijnitz… - Radiation …, 2020 - Springer
Lung, breast, and esophageal cancer represent three common malignancies with high
incidence and mortality worldwide. The management of these tumors critically relies on …

Radiation-induced lung injury: latest molecular developments, therapeutic approaches, and clinical guidance

L Lu, C Sun, Q Su, Y Wang, J Li, Z Guo, L Chen… - Clinical and …, 2019 - Springer
Cancer research has advanced throughout the years with respect to the personalization of
the treatments and to targeting cancer-related molecular signatures on different organs. Still …

[HTML][HTML] Inflammatory caspases drive pyroptosis in acute lung injury

B Liu, R He, L Zhang, B Hao, W Jiang… - Frontiers in …, 2021 - frontiersin.org
Acute lung injury (ALI), a critical respiratory disorder that causes diffuse alveolar injury leads
to high mortality rates with no effective treatment. ALI is characterized by varying degrees of …

[HTML][HTML] Pneumonitis resulting from radiation and immune checkpoint blockade illustrates characteristic clinical, radiologic and circulating biomarker features

JD Schoenfeld, M Nishino, M Severgnini… - … for immunotherapy of …, 2019 - Springer
Background Pneumonitis is a potential consequence of both lung-directed radiation and
immune checkpoint blockade (ICB), particularly treatment with PD-1/PD-L1 inhibitors …