Adenosine is an important mediator of ethanol intoxication. In vitro, ethanol stimulates
adenosine signaling by inhibiting the type 1 equilibrative nucleoside transporter (ENT1) …

Alcohol-sensitive type 1 equilibrative nucleoside transporter (ENT1) regulates adenosine-
mediated glutamate neurotransmission in the brain. Our behavioral studies suggest that the …

Adenosine signaling is implicated in several neuropsychiatric disorders, including
alcoholism. Among its diverse functions in the brain, adenosine regulates glutamate release …

Background Mice lacking type 1 equilibrative nucleoside transporter (ENT1−/−) exhibit
increased ethanol-preferring behavior compared with wild-type littermates. This phenotype …

Adenosine signaling has been implicated in the pathophysiology of many psychiatric
disorders including alcoholism. Striatal adenosine A2A receptors (A2AR) play an essential …

In the central nervous system (CNS), adenosine plays an important role in regulating
neuronal activity and modulates signaling by other neurotransmitters, including GABA …

Activation of adenosine receptors in the brain reduces anxiety‐like behavior in animals and
humans. Because nucleoside transporters regulate adenosine levels, we used mice lacking …

Background: Recent findings suggest that adenosine is involved in the neural and
behavioral effects of ethanol (EtOH). Studies in neural cell culture show that EtOH, via …

Adenosine is an important endogenous purine neuromodulator in the central nervous
system that modulates many important cellular processes in neurons. The physiological …

Adenosine signaling has been implicated in the pathophysiology of alcohol use disorders
and other psychiatric disorders such as anxiety and depression. Numerous studies have …