Alternative polyadenylation transcriptome-wide association study identifies APA-linked susceptibility genes in brain disorders
Alternative polyadenylation (APA) plays an essential role in brain development; however,
current transcriptome-wide association studies (TWAS) largely overlook APA in nominating …
current transcriptome-wide association studies (TWAS) largely overlook APA in nominating …
APAatlas: decoding alternative polyadenylation across human tissues
Alternative polyadenylation (APA) is an RNA-processing mechanism on the 3′ terminus
that generates distinct isoforms of mRNAs and/or other RNA polymerase II transcripts with …
that generates distinct isoforms of mRNAs and/or other RNA polymerase II transcripts with …
3′ aQTL-atlas: an atlas of 3′ UTR alternative polyadenylation quantitative trait loci across human normal tissues
Genome-wide association studies (GWAS) have identified thousands of non-coding single-
nucleotide polymorphisms (SNPs) associated with human traits and diseases. However …
nucleotide polymorphisms (SNPs) associated with human traits and diseases. However …
Alternative cleavage and polyadenylation of genes associated with protein turnover and mitochondrial function are deregulated in Parkinson's, Alzheimer's and ALS …
R Patel, C Brophy, M Hickling, J Neve, A Furger - BMC Medical Genomics, 2019 - Springer
Background Transcriptome wide changes have been assessed extensively during the
progression of neurodegenerative diseases. Alternative polyadenylation (APA) occurs in …
progression of neurodegenerative diseases. Alternative polyadenylation (APA) occurs in …
ipaQTL-atlas: an atlas of intronic polyadenylation quantitative trait loci across human tissues
Functional interpretation of disease-associated non-coding variants remains a significant
challenge in the post-GWAS era. Our recent study has identified 3′ UTR alternative …
challenge in the post-GWAS era. Our recent study has identified 3′ UTR alternative …
PolyA-miner: Accurate assessment of differential alternative poly-adenylation from 3′ Seq data using vector projections and non-negative matrix factorization
Almost 70% of human genes undergo alternative polyadenylation (APA) and generate
mRNA transcripts with varying lengths, typically of the 3′ untranslated regions (UTR). APA …
mRNA transcripts with varying lengths, typically of the 3′ untranslated regions (UTR). APA …
APAlyzer: a bioinformatics package for analysis of alternative polyadenylation isoforms
Most eukaryotic genes produce alternative polyadenylation (APA) isoforms. APA is
dynamically regulated under different growth and differentiation conditions. Here, we …
dynamically regulated under different growth and differentiation conditions. Here, we …
An atlas of alternative polyadenylation quantitative trait loci contributing to complex trait and disease heritability
Genome-wide association studies have identified thousands of noncoding variants
associated with human traits and diseases. However, the functional interpretation of these …
associated with human traits and diseases. However, the functional interpretation of these …
Alternative polyadenylation alters protein dosage by switching between intronic and 3′ UTR sites
Alternative polyadenylation (APA) creates distinct transcripts from the same gene by
cleaving the pre-mRNA at poly (A) sites that can lie within the 3′ untranslated region (3 …
cleaving the pre-mRNA at poly (A) sites that can lie within the 3′ untranslated region (3 …
Accurate transcriptome-wide identification and quantification of alternative polyadenylation from RNA-seq data with APAIQ
Alternative polyadenylation (APA) enables a gene to generate multiple transcripts with
different 3′ ends, which is dynamic across different cell types or conditions. Many …
different 3′ ends, which is dynamic across different cell types or conditions. Many …