Regulation of the phosphoprotein phosphatase 2A system and its modulation during oxidative stress: A potential therapeutic target?
IS Elgenaidi, JP Spiers - Pharmacology & therapeutics, 2019 - Elsevier
Phosphoprotein phosphatases are of growing interest in the pathophysiology of many
diseases and are often the neglected partner of protein kinases. One family member, PP2A …
diseases and are often the neglected partner of protein kinases. One family member, PP2A …
Protein phosphatase 2A as therapeutic targets in various disease models
R Baskaran, BK Velmurugan - Life sciences, 2018 - Elsevier
There are a large number of signalling pathways responsible for transmitting information
within the cell. Although cellular signalling is thought to be majorly governed by protein …
within the cell. Although cellular signalling is thought to be majorly governed by protein …
[HTML][HTML] Protein phosphatase 2A as a therapeutic target in inflammation and neurodegeneration
AR Clark, M Ohlmeyer - Pharmacology & therapeutics, 2019 - Elsevier
Abstract Protein phosphatase 2A (PP2A) is a highly complex heterotrimeric enzyme that
catalyzes the selective removal of phosphate groups from protein serine and threonine …
catalyzes the selective removal of phosphate groups from protein serine and threonine …
The biogenesis of active protein phosphatase 2A holoenzymes: a tightly regulated process creating phosphatase specificity
W Sents, E Ivanova, C Lambrecht, D Haesen… - The FEBS …, 2013 - Wiley Online Library
Protein phosphatase type 2A (PP2A) enzymes constitute a large family of Ser/Thr
phosphatases with multiple functions in cellular signaling and physiology. The composition …
phosphatases with multiple functions in cellular signaling and physiology. The composition …
[HTML][HTML] Targeting protein phosphatases for the treatment of inflammation-related diseases: From signaling to therapy
J Pan, L Zhou, C Zhang, Q Xu, Y Sun - Signal transduction and targeted …, 2022 - nature.com
Inflammation is the common pathological basis of autoimmune diseases, metabolic
diseases, malignant tumors, and other major chronic diseases. Inflammation plays an …
diseases, malignant tumors, and other major chronic diseases. Inflammation plays an …
[HTML][HTML] Redox inhibition of protein phosphatase PP2A: Potential implications in oncogenesis and its progression
D Raman, S Pervaiz - Redox Biology, 2019 - Elsevier
Cellular processes are dictated by the active signaling of proteins relaying messages to
regulate cell proliferation, apoptosis, signal transduction and cell communications. An …
regulate cell proliferation, apoptosis, signal transduction and cell communications. An …
All roads lead to PP 2A: exploiting the therapeutic potential of this phosphatase
J Sangodkar, CC Farrington, K McClinch… - The FEBS …, 2016 - Wiley Online Library
Protein phosphatase 2A (PP 2A) is a serine/threonine phosphatase involved in the
regulation of many cellular processes. A confirmed tumor suppressor protein, PP 2A is …
regulation of many cellular processes. A confirmed tumor suppressor protein, PP 2A is …
Monitoring protein phosphatase 1 isoform levels as a marker for cellular stress
FC Amador, AG Henriques, OABC e Silva… - Neurotoxicology and …, 2004 - Elsevier
Reversible protein phosphorylation is a central mechanism regulating many biological
functions, and abnormal protein phosphorylation can have a devastating impact on cellular …
functions, and abnormal protein phosphorylation can have a devastating impact on cellular …
Structure, regulation, and pharmacological modulation of PP2A phosphatases
C Lambrecht, D Haesen, W Sents, E Ivanova… - Phosphatase …, 2013 - Springer
Protein phosphatases of the type 2A family (PP2A) represent a major fraction of cellular
Ser/Thr phosphatase activity in any given human tissue. In this review, we describe how the …
Ser/Thr phosphatase activity in any given human tissue. In this review, we describe how the …
Therapeutic targeting of PP2A
Abstract Protein phosphatase 2A (PP2A) is a major serine/threonine phosphatase that
regulates many cellular processes. Given the central role of PP2A in regulating diverse …
regulates many cellular processes. Given the central role of PP2A in regulating diverse …