A new synthesis of fully phosphorylated flavones as potent pancreatic cholesterol esterase inhibitors

G Peng, Y Du, Y Wei, J Tang, AY Peng… - Organic & Biomolecular …, 2011 - pubs.rsc.org
Five flavones possessing one to four phenolic groups were fully phosphorylated efficiently
and the obtained compounds showed excellent pancreatic cholesterol esterase (CEase) …

Synthesis and biological evaluation of phosphorylated flavonoids as potent and selective inhibitors of cholesterol esterase

Y Wei, AY Peng, B Wang, L Ma, G Peng, Y Du… - European Journal of …, 2014 - Elsevier
A series of phosphorylated flavonoids were synthesized and investigated in vitro as
inhibitors of pancreatic cholesterol esterase (CEase) and acetylcholinesterase (AChE). The …

Inhibition of porcine liver carboxylesterase by phosphorylated flavonoids

Y Wei, AY Peng, J Huang - Chemico-biological interactions, 2013 - Elsevier
We have recently synthesized a series of phosphorylated flavonoids and identified some of
them as potent inhibitors of pancreatic cholesterol esterase (CEase) with excellent selectivity …

Phosphaisocoumarins as a new class of potent inhibitors for pancreatic cholesterol esterase

B Li, B Zhou, H Lu, L Ma, AY Peng - European journal of medicinal …, 2010 - Elsevier
Due to the importance of pancreatic cholesterol esterase (CEase) as a potential target in
atherosclerosis and for the development of hypocholesterolemic agents, there are …

Benzoflavones as cholesterol esterase inhibitors: Synthesis, biological evaluation and docking studies

H Singh, JV Singh, MK Gupta, P Singh… - Bioorganic & Medicinal …, 2017 - Elsevier
Abstract A library of forty 7, 8-benzoflavone derivatives was synthesized and evaluated for
their inhibitory potential against cholesterol esterase (CEase). Among all the synthesized …

Synthesis of Aryl α, α‐Difluoroalkyl Ketones as Potent Inhibitors of Cholesterol Esterase

G Lin, HC Liu, FC Wu, SJ Chen - Journal of the Chinese …, 1994 - Wiley Online Library
Aryl α, α‐difluoroalkyl ketones were synthesized from the reaction of ethyl α, α‐
difluoroacylate with aryl lithium at− 78° C or from the coupling of aryl iododifluoromethyl …

New cholesterol esterase inhibitors based on rhodanine and thiazolidinedione scaffolds

S Heng, W Tieu, S Hautmann, K Kuan… - Bioorganic & medicinal …, 2011 - Elsevier
We present a new class of inhibitors of pancreatic cholesterol esterase (CEase) based on
'priviledged'5-benzylidenerhodanine and 5-benzylidene-2, 4-thiazolidinedione structural …

Isocoumarin-based inhibitors of pancreatic cholesterol esterase

JJ Heynekamp, LA Hunsaker, TA Vander Jagt… - Bioorganic & medicinal …, 2008 - Elsevier
Pancreatic cholesterol esterase (CEase), which is secreted from the exocrine pancreas, is a
serine hydrolase that aids in the bile salt-dependent hydrolysis of dietary cholesteryl esters …

Synthesis and evaluation of a new series of tri‐, di‐, and mono‐N‐alkylcarbamylphloroglucinols as conformationally constrained inhibitors of cholesterol esterase

MC Lin, GZ Lin, CI Hwang, SY Jian, J Lin… - Protein …, 2012 - Wiley Online Library
Tri‐N‐alkylcarbamylphloroglucinols (1–4) are synthesized as conformationally constrained
analogs of triacylglycerols (TGs) to probe Jenck's proximity effect in the cholesterol esterase …

Isolation, characterization and biological activities of novel triprenyl phenols as pancreatic cholesterol esterase inhibitors produced by Stachybotrys sp. F-1839

K Sakai, K Watanabe, K Masuda, M Tsuji… - The Journal of …, 1995 - jstage.jst.go.jp
Tentriprenyl phenol metabolites were isolated as inhibitors of pancreatic cholesterol
esterase from cultures of Stachybotrys sp. F-1839 by solvent extraction and …