Skeletal muscle requires a highly orchestrated coordination between multiple cell types and
their microenvironment to exert its function and to maintain its homeostasis and regenerative …

The extracellular matrix (ECM) is an interconnected macromolecular scaffold occupying the
space between cells. Amongst other functions, the ECM provides structural support to …

Skeletal muscle is endowed with a remarkable capacity for regeneration, primarily due to the
reserve pool of muscle resident satellite cells. The satellite cell is the physiologically …

Age‐related declines in skeletal muscle regeneration have been attributed to muscle stem
cell (MuSC) dysfunction. Aged MuSCs display a fibrogenic conversion, leading to fibrosis …

Muscle stem cells (MuSCs) exhibit distinct behavior during successive phases of
developmental myogenesis. However, how their transition to adulthood is regulated is …

During aging, the regenerative capacity of skeletal muscle decreases due to intrinsic
changes in muscle stem cells (MuSCs) and alterations in their niche. Here, we use …

Skeletal muscle stem cells, or satellite cells (SCs), are essential to regenerate and maintain
muscle. Quiescent SCs reside in an asymmetric niche between the basal lamina and …

Skeletal muscle mass, function, and repair capacity all progressively decline with aging,
restricting mobility, voluntary function, and quality of life. Skeletal muscle repair is facilitated …

Skeletal muscle represents the largest body-composition component in humans. In addition
to its primary function in the maintenance of upright posture and the production of …

The regulation of stem cells that maintain and regenerate postnatal tissues depends on
extrinsic signals originating from their microenvironment, commonly referred to as the stem …