Cell-to-cell transmission of vaccinia virus can be mediated by enveloped virions that remain
attached to the outer surface of the cell or those released into the medium. During egress …

Vaccinia virus produces several forms of infectious virions. Intracellular mature virions (IMV)
assemble in areas close to the cell nucleus. Some IMV acquire an envelope from …

Two mechanisms have been proposed for the intracellular movement of enveloped vaccinia
virus virions: rapid actin polymerization and microtubule association. The first mechanism is …

Vaccinia virus (VACV) intracellular enveloped virus (IEV) particles are transported to the cell
periphery on microtubules where they fuse with the plasma membrane to form cell …

The vaccinia virus (VV) F12L gene encodes a 65 kDa protein that is expressed late during
infection and is important for plaque formation, EEV production and virulence. Here we have …

Vaccinia virus (VACV) spreads across cell monolayers fourfold faster than predicted from its
replication kinetics. Early after infection, infected cells repulse some superinfecting …

Viruses are obligate intracellular parasites that are critically dependent on their hosts to
replicate and generate new progeny. To achieve this goal, viruses have evolved numerous …

Vaccinia virus envelope protein A27 has multiple functions and is conserved in the
Orthopoxvirus genus of the poxvirus family. A27 protein binds to cell surface heparan …

We previously showed that infection with vaccinia virus (VV) induces cell motility,
characterized by contractility and directed migration. Motility is temporally regulated because …

Prior to being released from the infected cell, intracellular enveloped vaccinia virus particles
are transported from their perinuclear assembly site to the plasma membrane along …