Role of microRNAs in tumor progression by regulation of kinesin motor proteins

AN Shad, A Fanoodi, A Maharati, I Akhlaghipour… - International Journal of …, 2024 - Elsevier
Aberrant cell proliferation is one of the main characteristics of tumor cells that can be
affected by many cellular processes and signaling pathways. Kinesin superfamily proteins …

[HTML][HTML] Overexpression of KIF2A is suppressed by miR-206 and associated with poor prognosis in ovarian cancer

N Sheng, YZ Xu, QH Xi, HY Jiang, CY Wang… - Cellular Physiology and …, 2018 - karger.com
Background/Aims: This study aimed to investigate the expression and prognostic value of
kinesin family member 2A (KIF2A) and the suppression effects of microRNA-206 (miR-206) …

KIF2A silencing inhibits the proliferation and migration of breast cancer cells and correlates with unfavorable prognosis in breast cancer

J Wang, S Ma, R Ma, X Qu, W Liu, C Lv, S Zhao… - Bmc Cancer, 2014 - Springer
Background Kinesin family member 2a (KIF2A), a type of motor protein found in eukaryotic
cells, is associated with development and progression of various human cancers. The role of …

Pan-cancer analysis of kinesin family members with potential implications in prognosis and immunological role in human cancer

M Zhong, L Gong, N Li, H Guan, K Gong… - Frontiers in …, 2023 - frontiersin.org
Background Kinesin is a molecular motor for transporting “goods” within cells and plays a
key role in many types of tumors. The multi-angle study of kinesin at the pan-cancer level is …

Down‐regulation of KIF 2A inhibits gastric cancer cell invasion via suppressing MT 1‐MMP

P Zhao, F Lan, H Zhang, G Zeng… - Clinical and Experimental …, 2018 - Wiley Online Library
Gastric cancer accounts for a sizeable proportion of global cancer mortality with high
morbidity and poor prognosis. Kinesin superfamily proteins (KIF s) are microtubule …

Regulation of KIF2A by Antitumor miR-451a Inhibits Cancer Cell Aggressiveness Features in Lung Squamous Cell Carcinoma

A Uchida, N Seki, K Mizuno, Y Yamada, S Misono… - Cancers, 2019 - mdpi.com
In the human genome, miR-451a is encoded close to the miR-144 on chromosome region
17q11. 2. Our previous study showed that both strands of pre-miR-144 acted as antitumor …

Characterization of kinesin family member 2C as a proto-oncogene in cervical cancer

J Yang, Z Wu, L Yang, JH Jeong, Y Zhu, J Lu… - Frontiers in …, 2022 - frontiersin.org
Kinesin family member 2C (KIF2C) is known as an oncogenic gene to regulate tumor
progression and metastasis. However, its pan-cancer analysis has not been reported. In this …

[HTML][HTML] KIF2A promotes the progression via AKT signaling pathway and is upregulated by transcription factor ETV4 in human gastric cancer

X Zhang, Y Wang, X Liu, A Zhao, Z Yang, F Kong… - Biomedicine & …, 2020 - Elsevier
Kinesin family protein 2A (KIF2A), an M-type nonmotile microtubule depolymerase, plays
essential roles in development and progression of various human cancers. However, its …

KIF2C exerts an oncogenic role in nonsmall cell lung cancer and is negatively regulated by miR‐325‐3p

H Gan, L Lin, N Hu, Y Yang, Y Gao… - Cell biochemistry …, 2019 - Wiley Online Library
Nonsmall cell lung cancer (NSCLC) is one of the leading causes of cancer‐related death
worldwide. Kinesin family member 2C (KIF2C), a modulator in microtubule …

[HTML][HTML] Comprehensive analysis of the effects of KIF2C on prognosis, biological functions and immune infiltration in PAAD

J Xiong, R Wu, A He, P Hou, J Wang, R Zhang, W Liao… - Tissue and Cell, 2022 - Elsevier
Kinesin family member 2 C (KIF2C), a modulator of microtubule depolymerization, bipolar
spindle formation, and chromosome segregation, has been reported to play roles in cancer …