Despite considerable efforts to prevent and treat ischemic cardiomyopathy (ICM), effective
therapies remain lacking, in part owing to the complexity of the underlying molecular …

Myocardial infarction (MI) is a leading cause of morbidity and mortality worldwide. As
mitochondrial dysfunction critically contributes to the pathogenesis of MI, intensive research …

Myocardial infarction (MI) is the irreversible death of cardiomyocyte secondary to prolonged
lack of oxygen or fresh blood supply. Historically considered as merely cardiomyocyte …

Ischemic cardiomyopathy (ICM) is a special type of coronary heart disease or an advanced
stage of the disease, which is related to the pathological mechanism of primary dilated …

Mitochondrial damage is a critical contributor to cardiac ischemia/reperfusion (I/R) injury.
Mitochondrial quality control (MQC) mechanisms, a series of adaptive responses that …

Thrombolytic therapy and revascularization strategies create a complete recanalization of
the occluded epicardial coronary artery in patients with myocardial infarction (MI). However …

Acute myocardial infarction (AMI) and the heart failure (HF) that often follows are among the
leading causes of death and disability worldwide. As such, new treatments are needed to …

The mitochondrion is a vital component in cellular energy metabolism and intracellular
signaling processes. Mitochondria are involved in a myriad of complex signaling cascades …

Mitochondrial dysfunction has been regarded as a hallmark of diabetic cardiomyopathy. In
addition to their canonical metabolic actions, mitochondria influence various other aspects of …

Endothelial cells (ECs) constitute the innermost layer in all blood vessels to maintain the
structural integrity and microcirculation function for coronary microvasculature. Impaired …