Replication-competent latent HIV-1 proviruses that persist in the genomes of a very small
subset of resting memory T cells in infected individuals under life-long antiretroviral therapy …

Although potent combination antiretroviral therapy can effectively block viral replication in
the host, human immunodeficiency virus (HIV) persists due to the existence of latent but …

Intensive antiretroviral therapy successfully suppresses viral replication but is unable to
eradicate the virus. HIV persists in a small number of resting memory T cells where HIV has …

Strategies to purge the latent proviral pool require nontoxic activator molecules. The multiple
restrictions imposed on latent proviruses that need to be overcome suggest that proviral …

HIV-1 establishes a life-long infection when proviral DNA integrates into the host genome.
The provirus can then either actively transcribe RNA or enter a latent state, without viral …

HIV-1 can avoid host immune responses and antiretroviral drugs through the latent infection
of resting memory CD4+ T cells. Recently, latent viral genomes have been shown to reside …

Eradication of HIV-1 from an infected individual cannot be achieved by current regimens.
Viral reservoirs established early during the infection remain unaffected by anti-retroviral …

The persistence of HIV-1 latent reservoirs represents a major barrier to virus eradication in
infected patients under HAART since interruption of the treatment inevitably leads to a …

Highly active antiretroviral therapy (HAART) has limited the replication and spread of the
human immunodeficiency virus (HIV). However, despite treatment, HIV infection persists in …

Three decades of extensive work in the HIV field have revealed key viral and host cell
factors controlling proviral transcription. Various models of transcriptional regulation have …