Environmental sensing by mature B cells is controlled by the transcription factors PU. 1 and SpiB
Humoral immunity requires B cells to respond to multiple stimuli, including antigen,
membrane and soluble ligands, and microbial products. Ets family transcription factors …
membrane and soluble ligands, and microbial products. Ets family transcription factors …
[HTML][HTML] Defective B cell receptor‐mediated responses in mice lacking the Ets protein, Spi‐B
GH Su, HM Chen, N Muthusamy… - The EMBO …, 1997 - embopress.org
Spi‐B is a hematopoietic‐specific Ets family transcription factor closely related to PU. 1.
Previous gene targeting experiments have shown that PU. 1 is essential for the production of …
Previous gene targeting experiments have shown that PU. 1 is essential for the production of …
Surprising new roles for PU. 1 in the adaptive immune response
The ETS family transcription factor PU. 1 is one of the best‐studied regulators of
hematopoiesis. While research over the past two decades has established that PU. 1 is …
hematopoiesis. While research over the past two decades has established that PU. 1 is …
The development of functional B lymphocytes in conditional PU. 1 knock-out mice
An abundance of research has entrenched the view that the Ets domain containing
transcription factor PU. 1 is fundamental to the development and function of B lymphocytes …
transcription factor PU. 1 is fundamental to the development and function of B lymphocytes …
Deletion of genes encoding PU. 1 and Spi-B in B cells impairs differentiation and induces pre-B cell acute lymphoblastic leukemia
KM Sokalski, SKH Li, I Welch… - Blood, The Journal …, 2011 - ashpublications.org
The E26 transformation-specific (Ets) transcription factor PU. 1 is required to generate
lymphoid progenitor cells from hematopoietic stem cells, but it is not required to generate B …
lymphoid progenitor cells from hematopoietic stem cells, but it is not required to generate B …
Analysis of gene expression and Ig transcription in PU. 1/Spi-B-deficient progenitor B cell lines
BL Schweitzer, RP DeKoter - The Journal of Immunology, 2004 - journals.aai.org
A number of presumptive target genes for the Ets-family transcription factor PU. 1 have been
identified in the B cell lineage. However, the precise function of PU. 1 in B cells has not been …
identified in the B cell lineage. However, the precise function of PU. 1 in B cells has not been …
PU. 1/Spi-B regulation of c-rel is essential for mature B cell survival
Abstract PU. 1+/− Spi-B−/− mice exhibit reduced numbers of immature and mature B
lymphocytes, which exhibit severe defects in response to BCR-mediated stimulation and …
lymphocytes, which exhibit severe defects in response to BCR-mediated stimulation and …
Opposing roles for the related ETS-family transcription factors Spi-B and Spi-C in regulating B cell differentiation and function
AS Laramée, H Raczkowski, P Shao, C Batista… - Frontiers in …, 2020 - frontiersin.org
Generation of specific antibodies during an immune response to infection or vaccination
depends on the ability to rapidly and accurately select clones of antibody-secreting B …
depends on the ability to rapidly and accurately select clones of antibody-secreting B …
PU. 1 expression in T follicular helper cells limits CD40L-dependent germinal center B cell development
PU. 1 is an ETS family transcription factor that is important for the development of multiple
hematopoietic cell lineages. Previous work demonstrated a critical role for PU. 1 in …
hematopoietic cell lineages. Previous work demonstrated a critical role for PU. 1 in …
SPI-B activates transcription via a unique proline, serine, and threonine domain and exhibits DNA binding affinity differences from PU. 1
SPI-B is a B lymphocyte-specific Ets transcription factor that shares a high degree of
similarity with PU. 1/SPI-1. In direct contrast to PU. 1−/− mice that die in utero and lack …
similarity with PU. 1/SPI-1. In direct contrast to PU. 1−/− mice that die in utero and lack …