In recent years, studies on the intracellular pathogen Francisella tularensis have greatly
intensified, generating a wealth of new information on the interaction of this organism with …

Studies of immune responses to Francisella have been conducted for well over 50 years.
Here, the basic parameters of innate and adaptive immune responses to Francisella are …

Francisella tularensis is an intracellular Gram-negative bacterium that causes life-
threatening tularemia. Although the prevalence of natural infection is low, F. tularensis …

Monocytic cells constitute an important defense mechanism against invading pathogens by
recognizing conserved pathogens components. The recognition leads to activation of …

Very little is known about virulence mechanisms of the highly virulent bacterium Francisella
tularensis. Specific genetic features of F. tularensis have been obstacles for the …

Over the last decade, studies on the virulence of the highly pathogenic intracellular bacterial
pathogen Francisella tularensis have increased dramatically. The organism produces an …

Francisella tularensis is a Gram-negative intracellular pathogen and the causative agent of
the disease tularemia. Inhalation of as few as 10 bacteria is sufficient to cause severe …

Francisella tularensis is a highly virulent bacterial pathogen and the causative agent of
tularemia. Perhaps the most impressive feature of this bacterium is its ability to cause lethal …

Francisella tularensis is a facultative intracellular gram-negative pathogen and the
etiological agent of the zoonotic disease tularemia. Recent advances in the field of …

The role (s) of gamma interferon (IFN-gamma), tumor necrosis factor alpha (TNF-alpha), and
interleukin-4 (IL-4) in establishment and maintenance of protective immunity to Francisella …