Is NF-κB a good target for cancer therapy? Hopes and pitfalls

V Baud, M Karin - Nature reviews Drug discovery, 2009 - nature.com
Nuclear factor κB (NF-κB) transcription factors have a key role in many physiological
processes such as innate and adaptive immune responses, cell proliferation, cell death, and …

NF-κB in cancer—a friend turned foe

R Ravi, A Bedi - Drug resistance updates, 2004 - Elsevier
The nuclear factor of κB (NF-κB) family of heterodimeric transcription factors plays an
instrumental role in immune, inflammatory, and stress responses. NF-κB induces the …

Nuclear transcription factor-κB as a target for cancer drug development

A Garg, BB Aggarwal - Leukemia, 2002 - nature.com
Nuclear factor kappa B (NF-κB) is a family of inducible transcription factors found virtually
ubiquitously in all cells. Since its discovery by Sen and Baltimore in 1986, much has been …

[HTML][HTML] NF-kappaB: two sides of the same coin

BRB Pires, RCMC Silva, GM Ferreira, E Abdelhay - Genes, 2018 - mdpi.com
Nuclear Factor-kappa B (NF-κB) is a transcription factor family that regulates a large number
of genes that are involved in important physiological processes, including survival …

Pathogenetic importance and therapeutic implications of NF‐κB in lymphoid malignancies

KH Lim, Y Yang, LM Staudt - Immunological reviews, 2012 - Wiley Online Library
Derangement of the nuclear factor κB (NF‐κB) pathway initiates and/or sustains many types
of human cancer. B‐cell malignancies are particularly affected by oncogenic mutations …

Molecular pathways: the balance between cancer and the immune system challenges the therapeutic specificity of targeting nuclear factor-κB signaling for cancer …

KP Zeligs, MK Neuman, CM Annunziata - Clinical Cancer Research, 2016 - AACR
The NF-κB signaling pathway is a complex network linking extracellular stimuli to cell
survival and proliferation. Cytoplasmic signaling to activate NF-κB can occur as part of the …

NF-κB in cancer: from innocent bystander to major culprit

M Karin, Y Cao, FR Greten, ZW Li - Nature reviews cancer, 2002 - nature.com
Nuclear factor of κB (NF-κB) is a sequence-specific transcription factor that is known to be
involved in the inflammatory and innate immune responses. Although the importance of NF …

Nuclear factor-κB activation: from bench to bedside

G Sethi, B Sung, BB Aggarwal - Experimental biology and …, 2008 - journals.sagepub.com
Nuclear factor-κB (NF-κB) is a proinflammatory transcription factor that has emerged as an
important player in the development and progression of malignant cancers. NF-κB targets …

Nuclear factor-κB: a friend or a foe in cancer?

S Shishodia, BB Aggarwal - Biochemical pharmacology, 2004 - Elsevier
Nuclear transcription factor NF-κB, initially discovered as a factor in the nucleus of B cells
that binds to the enhancer of the kappa light chain of immunoglobulin, has since been …

NF-κB in cancer therapy

F Li, J Zhang, F Arfuso, A Chinnathambi, ME Zayed… - Archives of …, 2015 - Springer
The transcription factor nuclear factor kappa B (NF-κB) has attracted increasing attention in
the field of cancer research from last few decades. Aberrant activation of this transcription …