MLIF modulates microglia polarization in ischemic stroke by targeting eEF1A1
Y Liu, S Deng, Z Song, Q Zhang, Y Guo, Y Yu… - Frontiers in …, 2021 - frontiersin.org
Monocyte locomotion inhibitory factor (MLIF) is a heat-stable pentapeptide from Entamoeba
histolytica. Our previous study found that MLIF protects against ischemic stroke in rats and …
histolytica. Our previous study found that MLIF protects against ischemic stroke in rats and …
A pentapeptide monocyte locomotion inhibitory factor protects brain ischemia injury by targeting the eEF1A1/endothelial nitric oxide synthase pathway
Y Zhang, J Chen, F Li, D Li, Q Xiong, Y Lin, D Zhang… - Stroke, 2012 - Am Heart Assoc
Background and Purpose—Ischemic stroke is a major cause of death worldwide but lacks
viable treatment or treatment targets. Monocyte locomotion inhibitory factor (MLIF) is a small …
viable treatment or treatment targets. Monocyte locomotion inhibitory factor (MLIF) is a small …
MLIF alleviates SH-SY5Y neuroblastoma injury induced by oxygen-glucose deprivation by targeting eukaryotic translation elongation factor 1A2
Q Zhu, Y Zhang, Y Liu, H Cheng, J Wang, Y Zhang… - PloS one, 2016 - journals.plos.org
Monocyte locomotion inhibitory factor (MLIF), a heat-stable pentapeptide, has been shown
to exert potent anti-inflammatory effects in ischemic brain injury. In this study, we …
to exert potent anti-inflammatory effects in ischemic brain injury. In this study, we …
Neuroprotective effect of macrophage migration inhibitory factor (MIF) in a mouse model of ischemic stroke
JA Kim, YY Kim, SH Lee, C Jung, MH Kim… - International Journal of …, 2022 - mdpi.com
The mechanism of the neuroprotective effect of the macrophage migration inhibitory factor
(MIF) in vivo is unclear. We investigated whether the MIF promotes neurological recovery in …
(MIF) in vivo is unclear. We investigated whether the MIF promotes neurological recovery in …
LncRNA MEG3 regulates microglial polarization through KLF4 to affect cerebral ischemia-reperfusion injury
T Li, Y Luo, P Zhang, S Guo, H Sun… - Journal of Applied …, 2020 - journals.physiology.org
This study aimed to explore whether long noncoding RNA (lncRNA) maternally expressed
gene 3 (MEG3) affects the polarization of microglia in cerebral ischemia-reperfusion (I/R) …
gene 3 (MEG3) affects the polarization of microglia in cerebral ischemia-reperfusion (I/R) …
Macrophage migration inhibitory factor mediates neuroprotective effects by regulating inflammation, apoptosis and autophagy in Parkinson's disease
S Li, K Nie, Q Zhang, M Guo, Y Qiu, Y Li, Y Gao… - Neuroscience, 2019 - Elsevier
The influence of neuroinflammation in the development and progression of Parkinson's
disease (PD) remains unknown. Macrophage migration inhibitory factor (MIF) is a …
disease (PD) remains unknown. Macrophage migration inhibitory factor (MIF) is a …
Lack of macrophage migration inhibitory factor in mice does not affect hallmarks of the inflammatory/immune response during the first week after stroke
Background Macrophage migration inhibitory factor (MIF) has been proposed to play a
detrimental role in stroke. We recently showed that MIF promotes neuronal death and …
detrimental role in stroke. We recently showed that MIF promotes neuronal death and …
[HTML][HTML] FAM19A3, a novel secreted protein, modulates the microglia/macrophage polarization dynamics and ameliorates cerebral ischemia
Y Shao, T Deng, T Zhang, P Li, Y Wang - FEBS letters, 2015 - Elsevier
In this study, we have identified FAM19A3 as a gene that is significantly upregulated in the
microglia in the middle cerebral artery occlusion (MCAO) mouse model. FAM19A3 …
microglia in the middle cerebral artery occlusion (MCAO) mouse model. FAM19A3 …
Epigenetic regulations of microglia/macrophage polarization in ischemic stroke
M Qiu, E Xu, L Zhan - Frontiers in Molecular Neuroscience, 2021 - frontiersin.org
Ischemic stroke is one of the leading causes of death and disability worldwide. Microglia/
macrophages (MMs)-mediated neuroinflammation contributes significantly to the …
macrophages (MMs)-mediated neuroinflammation contributes significantly to the …
CKLF1 aggravates focal cerebral ischemia injury at early stage partly by modulating microglia/macrophage toward M1 polarization through CCR4
C Chen, SF Chu, QD Ai, Z Zhang, FF Guan… - Cellular and molecular …, 2019 - Springer
CKLF1 is a chemokine with increased expression in ischemic brain, and targeting CKLF1
has shown therapeutic effects in cerebral ischemia model. Microglia/macrophage …
has shown therapeutic effects in cerebral ischemia model. Microglia/macrophage …