Targeting MET in cancer therapy

HN Mo, P Liu - Chronic diseases and translational medicine, 2017 - mednexus.org
MET encodes a receptor tyrosine kinase c-MET for hepatocyte growth factor (HGF). The
specific combination of c-MET and HGF activates downstream signaling pathways to trigger …

Emerging molecular targets in oncology: clinical potential of MET/hepatocyte growth-factor inhibitors

EC Smyth, F Sclafani, D Cunningham - OncoTargets and therapy, 2014 - Taylor & Francis
The MET/hepatocyte growth-factor (HGF) signaling pathway plays a key role in the
processes of embryogenesis, wound healing, and organ regeneration. Aberrant activation of …

MET targeting: time for a rematch

JP Koch, DM Aebersold, Y Zimmer, M Medová - Oncogene, 2020 - nature.com
MET, the receptor tyrosine kinase (RTK) for hepatocyte growth factor, is a proto-oncogene
involved in embryonic development and throughout life in homeostasis and tissue …

The potential roles of hepatocyte growth factor (HGF)-MET pathway inhibitors in cancer treatment

RA Parikh, P Wang, JH Beumer, E Chu… - OncoTargets and …, 2014 - Taylor & Francis
MET is located on chromosome 7q31 and is a proto-oncogene that encodes for hepatocyte
growth factor (HGF) receptor, a member of the receptor tyrosine kinase (RTK) family. HGF …

Targeting the hepatocyte growth factor–cMET axis in cancer therapy

GR Blumenschein Jr, GB Mills… - Journal of clinical …, 2012 - ascopubs.org
The hepatocyte growth factor (HGF) and its receptor, the transmembrane tyrosine kinase
cMET, promote cell proliferation, survival, motility, and invasion as well as morphogenic …

[HTML][HTML] MET signaling: novel targeted inhibition and its clinical development in lung cancer

Y Feng, PS Thiagarajan, PC Ma - Journal of Thoracic Oncology, 2012 - Elsevier
MET is a versatile receptor tyrosine kinase within the human kinome which is activated by its
specific natural ligand hepatocyte growth factor (HGF). MET signaling plays an important …

c-MET as a potential therapeutic target and biomarker in cancer

JR Sierra, MS Tsao - Therapeutic advances in medical …, 2011 - journals.sagepub.com
The receptor tyrosine kinase c-MET and its ligand, hepatocyte growth factor (HGF), regulate
multiple cellular processes that stimulate cell proliferation, invasion and angiogenesis. This …

The emerging role of c‐met in carcinogenesis and clinical implications as a possible therapeutic target

A Faiella, F Riccardi, G Cartenì, M Chiurazzi… - Journal of …, 2022 - Wiley Online Library
Background. c‐MET is a receptor tyrosine kinase receptor (RTK) for the hepatocyte growth
factor (HGF). The binding of HGF to c‐MET regulates several cellular functions …

Targeting the HGF/Met signaling pathway in cancer therapy

F Cecchi, DC Rabe, DP Bottaro - Expert opinion on therapeutic …, 2012 - Taylor & Francis
Introduction: Under normal conditions, hepatocyte growth factor (HGF)-induced activation of
its cell surface receptor, the Met tyrosine kinase (TK), is tightly regulated by paracrine ligand …

Targeting MET as a strategy to overcome crosstalk-related resistance to EGFR inhibitors

MV Karamouzis, PA Konstantinopoulos… - The lancet …, 2009 - thelancet.com
The hepatocyte growth factor (HGF)–mesenchymal-epithelial transition factor (MET)
pathway has a key role in carcinogenesis; it is implicated in proliferation, inhibition of …