Microtubule dysfunction: a common feature of neurodegenerative diseases

A Sferra, F Nicita, E Bertini - International journal of molecular sciences, 2020 - mdpi.com
Neurons are particularly susceptible to microtubule (MT) defects and deregulation of the MT
cytoskeleton is considered to be a common insult during the pathogenesis of …

Altered microtubule dynamics in neurodegenerative disease: Therapeutic potential of microtubule-stabilizing drugs

KR Brunden, VMY Lee, AB Smith III… - Neurobiology of …, 2017 - Elsevier
Many neurodegenerative diseases are characterized by deficiencies in neuronal axonal
transport, a process in which cellular cargo is shuttled with the aid of molecular motors from …

Microtubule organization is essential for maintaining cellular morphology and function

L Huang, Y Peng, X Tao, X Ding, R Li… - Oxidative medicine …, 2022 - Wiley Online Library
Microtubules (MTs) are highly dynamic polymers essential for a wide range of cellular
physiologies, such as acting as directional railways for intracellular transport and position …

Microtubules: From understanding their dynamics to using them as potential therapeutic targets

Y Ilan - Journal of cellular physiology, 2019 - Wiley Online Library
Microtubules (MT) and actin microfilaments are dynamic cytoskeleton components involved
in a range of intracellular processes. MTs play a role in cell division, beating of cilia and …

Tubulin post‐translational modifications control neuronal development and functions

MJ Moutin, C Bosc, L Peris… - Developmental …, 2021 - Wiley Online Library
Microtubules (MTs) are an essential component of the neuronal cytoskeleton; they are
involved in various aspects of neuron development, maintenance, and functions including …

[HTML][HTML] Microtubule-targeting agents and neurodegeneration

Z Boiarska, D Passarella - Drug Discovery Today, 2021 - Elsevier
Highlights•Dysregulation of microtubule dynamics triggers neurodegeneration and
neurotoxicity.•MTAs are able to restore MT dynamics and disease-related pathology in …

Neurodegeneration and microtubule dynamics: death by a thousand cuts

J Dubey, N Ratnakaran, SP Koushika - Frontiers in cellular …, 2015 - frontiersin.org
Microtubules form important cytoskeletal structures that play a role in establishing and
maintaining neuronal polarity, regulating neuronal morphology, transporting cargo, and …

Tubulin post-translational modifications: the elusive roles of acetylation

B Carmona, HS Marinho, CL Matos, S Nolasco… - Biology, 2023 - mdpi.com
Simple Summary Microtubules (MTs) are dynamic structures that compose part of the cell
cytoskeleton. They play important roles in various cellular functions, such as intracellular …

Post‐translational modifications of tubulin in the nervous system

N Fukushima, D Furuta, Y Hidaka… - Journal of …, 2009 - Wiley Online Library
J. Neurochem.(2009) 109, 683–693. Abstract Many studies have shown that microtubules
(MTs) interact with MT‐associated proteins and motor proteins. These interactions are …

Microtubule-stabilizing agents as potential therapeutics for neurodegenerative disease

KR Brunden, JQ Trojanowski, AB Smith III… - Bioorganic & medicinal …, 2014 - Elsevier
Microtubules (MTs), cytoskeletal elements found in all mammalian cells, play a significant
role in cell structure and in cell division. They are especially critical in the proper functioning …