The NLRP3 inflammasome has been implicated in the pathogenesis of a wide variety of
human diseases. A few compounds have been developed to inhibit NLRP3 inflammasome …

The dysregulation of NLRP 3 inflammasome can cause uncontrolled inflammation and drive
the development of a wide variety of human diseases, but the medications targeting NLRP 3 …

Inflammasomes are multiprotein complexes that drive inflammation and contribute to
protective immunity against pathogens and immune pathology in autoinflammatory …

Danger signals are a hallmark of many common inflammatory diseases, and these stimuli
can function to activate the cytosolic innate immune signalling receptor NLRP3 (NOD-, LRR …

NLRP3 (NOD-, LRR-, and pyrin domain-containing protein 3) is a cytosolic pattern
recognition receptor (PRR) that recognizes multiple pathogen-associated molecular patterns …

The NLRP3 inflammasome is a cytoplasmic multiprotein complex, the assembly of which
can be initiated in response to various exogenous or endogenous danger signals …

Inhibiting the NLRP3 inflammasome mediates inflammation in an extensive number of
preclinical models. As excitement in this field has grown, several companies have recently …

Inhibition of the NLRP3 inflammasome is a promising strategy for the development of new
treatments for inflammatory diseases. MCC950 is a potent and specific small-molecule …

The nucleotide-binding, oligomerization domain-like receptor family pyrin domain containing
3 (NLRP3) inflammasome is a multiprotein complex that combines sensing, regulation, and …

The NACHT, leucine-rich repeat (LRR), and pyrin domain (PYD)-containing protein 3
(NLRP3) inflammasome is an intracellular sensing protein complex that plays a major role in …