Recent studies suggest a hierarchical model in which lineage-determining factors act in a
collaborative manner to select and prime cell-specific enhancers, thereby enabling signal …

Enhancers determine tissue-specific gene expression programs. Enhancers are marked by
high histone H3 lysine 4 mono-methylation (H3K4me1) and by the acetyl-transferase p300 …

Gene expression is controlled by the involvement of gene-proximal (promoters) and distal
(enhancers) regulatory elements. Our previous results demonstrated that a subset of gene …

Macrophages function as sentinel cells, which constantly monitor the host environment for
infection or injury. Macrophages have been shown to exhibit a spectrum of activated …

Monomethylation of histone H3 at lysine 4 (H3K4me1) and acetylation of histone H3 at
lysine 27 (H3K27ac) are correlated with transcriptionally engaged enhancer elements, but …

Toll-like receptor (TLR) activation induces inflammatory responses in macrophages by
activating temporally defined transcriptional cascades. Whether concurrent changes in the …

The inflammatory response requires coordinated activation of both transcription factors and
chromatin to induce transcription for defense against pathogens and environmental insults …

Macrophages are the prime innate immune cells of the inflammatory response, and the
combination of multiple signaling inputs derived from the recognition of host factors [eg …

The glucocorticoid receptor (GR) potently represses macrophage-elicited inflammation,
however, the underlying mechanisms remain obscure. Our genome-wide analysis in mouse …

The development and functional potential of metazoan cells is dependent on combinatorial
roles of transcriptional enhancers and promoters. Macrophages provide exceptionally …