Cinnamic aldehyde treatment alleviates chronic unexpected stress-induced depressive-like behaviors via targeting cyclooxygenase-2 in mid-aged rats
Y Yao, HY Huang, YX Yang, JY Guo - Journal of ethnopharmacology, 2015 - Elsevier
Ethnopharmacological relevance COX-2 has been considered as a potent molecular target
for prevention and therapy of depression. However, a recent study showed that COX-2 …
for prevention and therapy of depression. However, a recent study showed that COX-2 …
Chronic treatment with celecoxib reverses chronic unpredictable stress-induced depressive-like behavior via reducing cyclooxygenase-2 expression in rat brain
JY Guo, CY Li, YP Ruan, M Sun, XL Qi, BS Zhao… - European journal of …, 2009 - Elsevier
Recent clinical trails reported that adjunctive cyclooxygenase (COX)-2 inhibition with
celecoxib is beneficial in treating depression. However, another clinical study showed …
celecoxib is beneficial in treating depression. However, another clinical study showed …
COX-2 inhibition rescues depression-like behaviors via suppressing glial activation, oxidative stress and neuronal apoptosis in rats
Q Song, YB Feng, L Wang, J Shen, Y Li, C Fan… - …, 2019 - Elsevier
Depression is considered a neuropsychiatric condition which is associated with neuronal
injury within specific brain regions. We previously reported that cyclo-oxygenase (COX)-2, a …
injury within specific brain regions. We previously reported that cyclo-oxygenase (COX)-2, a …
Cyclooxygenase-2 signalling pathway in the cortex is involved in the pathophysiological mechanisms in the rat model of depression
Q Chen, Y Luo, S Kuang, Y Yang, X Tian, J Ma, S Mai… - Scientific reports, 2017 - nature.com
This study was designed to investigate the effect of the cortical cyclooxygenase-2 (COX2)
pathway on depressive behaviour in rats. Meloxicam, COX2 overexpressed lentivirus and …
pathway on depressive behaviour in rats. Meloxicam, COX2 overexpressed lentivirus and …
Quercetin mitigates depression-like behavior via the suppression of neuroinflammation and oxidative damage in corticosterone-induced mice
C Ge, S Wang, X Wu, L Lei - Journal of Chemical Neuroanatomy, 2023 - Elsevier
Depression is a clinically common and easily overlooked mental disease. Quercetin is a
flavonoid compound, which has anti-inflammatory and antioxidant roles. Previous reports …
flavonoid compound, which has anti-inflammatory and antioxidant roles. Previous reports …
Trans-cinnamaldehyde shows anti-depression effect in the forced swimming test and possible involvement of the endocannabinoid system
J Lin, Z Song, X Chen, R Zhao, J Chen, H Chen… - Biochemical and …, 2019 - Elsevier
Depression is a mental disease that significantly reduces the quality of patients' life. Around
322 million people of all ages carry the heavy burden of depression on a worldwide scale …
322 million people of all ages carry the heavy burden of depression on a worldwide scale …
Protective effects of zingerone against depression-like behavior and biochemical changes in chronic stressed rats: antioxidant effects
K Upadhyaya, PK Sharma, A Akhtar… - Journal of Medicinal …, 2022 - liebertpub.com
Ginger contains zingerone, an active constituent possessing antioxidant and
neuroprotective properties. The present study was designed to explore the efficacy of the …
neuroprotective properties. The present study was designed to explore the efficacy of the …
Indole-3-carbinol selectively prevents chronic stress-induced depression-but not anxiety-like behaviors via suppressing pro-inflammatory cytokine production and …
S Pan, Y Ma, R Yang, X Lu, Q You, T Ye… - Frontiers in …, 2022 - frontiersin.org
Indole-3-carbinol (I3C), a phytochemical enriched in most cruciferous vegetables, has been
shown to display various biological activities such as anti-oxidative stress, anti-inflammation …
shown to display various biological activities such as anti-oxidative stress, anti-inflammation …
The effects of cinnamaldehyde on acute or chronic stress-induced anxiety-related behavior and locomotion in male mice
Anxiety and stress are considered as universal psychiatric exhibitions of the present
societies and lifestyles. Several experiments have been conducted to examine natural …
societies and lifestyles. Several experiments have been conducted to examine natural …
[HTML][HTML] Chronic high dose of captopril induces depressive-like behaviors in mice: possible mechanism of regulatory T cell in depression
HS Park, A Han, HL Yeo, MJ Park, MJ You, HJ Choi… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Major depression has various types of symptoms and disease courses with inconsistent
response to monoamine-related antidepressants. Thus, monoamine theory may not be the …
response to monoamine-related antidepressants. Thus, monoamine theory may not be the …