Microvasculature plays a crucial role in the microenvironment, providing nutrients/drugs, and
facilitating the trafficking of immune cells. In previous studies, degraded microvascular …

Purpose/Objective (s) Half of the cancer patients are treated with radiotherapy to obtain
tumor control while minimizing radiation toxicity. In this context, hypoxia is known to …

Radiotherapy (RT) is the most common cancer treatment, and hypoxia is one of the main
causes of resistance to RT. We investigate how microvascular morphology affects radiation …

Oxygen is essential for human survival. Thanks to the systemic circulation and the
capillaries, oxygen is delivered to biological tissues. In the bloodstream, oxygen shows two …

Purpose Tumor oxygenation is one of the key features influencing the response of cells to
radiation and chemo therapies. This study presents a novel in silico tumor model simulating …

We address a mathematical model for oxygen transfer in the microcirculation. The model
includes blood flow and hematocrit transport coupled with the interstitial flow, oxygen …

Objective: The purpose of this study is to investigate how theoretical predictions of tumor
response to radiotherapy (RT) depend on the morphology and spatial representation of the …

Increased radio-sensitivity with increase in oxygen concentration across tumour-bearing
regions is a potentially important aspect of radiotherapy. Representation of the oxygen …

Malignant growth usually leads to the depletion of oxygen (O 2) supply in most solid tumors.
Hypoxia can cause resistance to standard radiotherapy, some chemotherapy and …

Radiation treatment is one of the most frequently used therapies in patients with cancer,
employed in approximately half of all patients. However, the use of radiation therapy is …