Accumulation of protease mutations among patients failing second-line antiretroviral therapy and response to salvage therapy in Nigeria
HE Rawizza, B Chaplin, ST Meloni, KM Darin… - PloS one, 2013 - journals.plos.org
Background To date, antiretroviral therapy (ART) guidelines and programs in resource-
limited settings (RLS) have focused on 1st-and 2nd-line (2 L) therapy. As programs …
limited settings (RLS) have focused on 1st-and 2nd-line (2 L) therapy. As programs …
Genotypic resistance at viral rebound among patients who received lopinavir/ritonavir-based or efavirenz-based first antiretroviral therapy in South Africa
Nonnucleoside reverse transcriptase inhibitor–drug resistance mutations (DRM) are
increasingly reported in Africans failing their first antiretroviral regimen. The Phidisa II trial …
increasingly reported in Africans failing their first antiretroviral regimen. The Phidisa II trial …
Virologic failure of protease inhibitor-based second-line antiretroviral therapy without resistance in a large HIV treatment program in South Africa
JH Levison, C Orrell, S Gallien, DR Kuritzkes, N Fu… - PloS one, 2012 - journals.plos.org
Background We investigated the prevalence of wild-type virus (no major drug resistance)
and drug resistance mutations at second-line antiretroviral treatment (ART) failure in a large …
and drug resistance mutations at second-line antiretroviral treatment (ART) failure in a large …
Protease inhibitor resistance is uncommon in HIV‐1 subtype C infected patients on failing second‐line lopinavir/r‐containing antiretroviral therapy in South Africa
CL Wallis, JW Mellors, WDF Venter… - AIDS research and …, 2011 - Wiley Online Library
Limited data exist on HIV‐1 drug resistance patterns in South Africa following second‐line
protease‐inhibitor containing regimen failure. This study examined drug resistance patterns …
protease‐inhibitor containing regimen failure. This study examined drug resistance patterns …
Evolution of protease inhibitor resistance in human immunodeficiency virus type 1 infected patients failing protease inhibitor monotherapy as second-line therapy in …
JA Thompson, C Kityo, D Dunn, A Hoppe… - Clinical infectious …, 2019 - academic.oup.com
Background Limited viral load (VL) testing in human immunodeficiency virus (HIV) treatment
programs in low-income countries often delays detection of treatment failure. The impact of …
programs in low-income countries often delays detection of treatment failure. The impact of …
Prevalence of antiretroviral drug resistance in patients who are not responding to protease inhibitor–based treatment: results from the first national survey in South …
K Steegen, M Bronze… - The Journal of …, 2016 - academic.oup.com
Limited data exist on human immunodeficiency virus type 1 (HIV-1) resistance in patients
who are not responding to protease inhibitor (PI)–based regimens in resource-limited …
who are not responding to protease inhibitor (PI)–based regimens in resource-limited …
Low lopinavir plasma or hair concentrations explain second-line protease inhibitor failures in a resource-limited setting
GU Van Zyl, TE Van Mens, H McIlleron… - JAIDS Journal of …, 2011 - journals.lww.com
Background: In resource-limited settings, many patients, with no prior protease inhibitor (PI)
treatment on a second-line, high genetic barrier, ritonavir-boosted PI-containing regimen …
treatment on a second-line, high genetic barrier, ritonavir-boosted PI-containing regimen …
Protease inhibitor resistance in the first 3 years of second-line antiretroviral therapy for HIV-1 in sub-Saharan Africa
TS Boender, RL Hamers, P Ondoa… - The Journal of …, 2016 - academic.oup.com
Background. As antiretroviral therapy (ART) programs in sub-Saharan Africa mature,
increasing numbers of persons with human immunodeficiency virus (HIV) infection will …
increasing numbers of persons with human immunodeficiency virus (HIV) infection will …
HIV drug resistance mutations among patients failing second-line antiretroviral therapy in Rwanda
JA Ndahimana, DJ Riedel, R Muhayimpundu… - 2016 - journals.sagepub.com
Background Studies of patients failing second-line antiretroviral therapy (ART) in resource-
limited settings (RLS) are few. Evidence suggests most patients who appear to be …
limited settings (RLS) are few. Evidence suggests most patients who appear to be …
Frequency of antiretroviral drug resistance mutations in HIV-1 strains from patients failing triple drug regimens
MA Winters, JD Baxter, DL Mayers… - Antiviral …, 2000 - journals.sagepub.com
The frequency of protease and reverse transcriptase (RT) gene mutations was determined in
HIV-1 strains from 153 patients entering the CPCRA 046 (GART) study who were failing …
HIV-1 strains from 153 patients entering the CPCRA 046 (GART) study who were failing …