Axonal loss is the key pathological substrate of neurological disability in demyelinating
disorders, including multiple sclerosis (MS). However, the consequences of demyelination …

Neurodegeneration in multiple sclerosis (MS) is related to inflammation and demyelination.
In acute MS lesions and experimental autoimmune encephalomyelitis focal immune attacks …

Multiple sclerosis (MS) is a chronic disease of the central nervous system, affecting more
than 2 million people worldwide. Traditionally considered an inflammatory demyelinating …

Axonal injury is a key feature of multiple sclerosis (MS) pathology and is currently seen as
the main correlate for permanent clinical disability. Although little is known about the …

Loss of the myelin sheath (demyelination) increases the vulnerability of axons to a variety of
insults, including the possibility of degeneration. Indeed, axonal degeneration is well …

Mitochondria are organelles responsible for bioenergetic metabolism, calcium homeostasis,
and signal transmission essential for neurons due to their high energy consumption …

Axonal degeneration contributes to permanent neurological disability in inherited and
acquired diseases of myelin. Mitochondrial dysfunction has been proposed as a major …

Understanding the mechanisms of axonal mitochondrial response to a disturbance in myelin
and determining if certain aspects of the axonal mitochondrial response to demyelinated …

Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous
system. Recent evidence suggests that dysfunction of surviving demyelinated axons and …

Axonal pathology in multiple sclerosis (MS) has been described for over a century, but new
insights into axonal loss and disability have refocused interest in this area. There is …