Invasive fungal infections are associated with very high mortality rates ranging from 20–90%
for opportunistic fungal pathogens such as Candida albicans, Cryptococcus neoformans …

The high incidence and mortality of invasive fungal infections and serious drug resistance
have become a global public health issue. The ability of fungal cells to form biofilms is an …

Biofilm formation is an important virulence factor for pathogenic fungi. Both yeasts and
filamentous fungi can adhere to biotic and abiotic surfaces, developing into highly organized …

Undeniably, new antifungal treatments are necessary against pathogenic fungi. Fungal
infections have significantly increased in recent decades, being highlighted as important …

Highlights•Fungal infections affect an expanding population of immunosuppressed
patients.•The current arsenal of antifungal drugs is exceedingly limited.•Toxicity problems …

The high rates of morbidity and mortality caused by fungal infections are associated with the
current limited antifungal arsenal and the high toxicity of the compounds. Additionally …

The development of new antifungal agents that target biofilms is an urgent need. Natural
products, mainly from the plant kingdom, represent an invaluable source of these entities …

Aspergillus fumigatus is a saprophytic, filamentous fungus found in soils and compost and
the causative agent of several pulmonary diseases in humans, birds, and other mammals. A …

Human fungal infections may fail to respond to contemporary antifungal therapies in vivo
despite in vitro fungal isolate drug susceptibility. Such a discrepancy between in vitro …

In nature, microorganisms prefer to reside in structured microbial communities, termed
biofilms, rather than as free-floating planktonic cells. Advantageous for the microorganisms …