Somatostatin receptor 2 knockout/lacZ knockin mice show impaired motor coordination and reveal sites of somatostatin action within the striatum

JP Allen, GJ Hathway, NJ Clarke… - European Journal of …, 2003 - Wiley Online Library
The peptide somatostatin can modulate the functional output of the basal ganglia. The exact
sites and mechanisms of this action, however, are poorly understood, and the physiological …

First localisation of somatostatin sst4 receptor protein in selected human brain areas: an immunohistochemical study

IS Selmer, M Schindler, PPA Humphrey… - Molecular brain …, 2000 - Elsevier
Somatostatin is known to have diverse neurophysiological effects in the mammalian CNS.
To date, genes for five different receptors, termed sst1–5, have been isolated. Recently …

Distribution, targeting, and internalization of the sst4 somatostatin receptor in rat brain

M Schreff, S Schulz, M Händel, G Keilhoff… - Journal of …, 2000 - Soc Neuroscience
Somatostatin mediates its diverse physiological effects through a family of five G-protein-
coupled receptors (sst1–sst5); however, knowledge about the distribution of individual …

Localization of five somatostatin receptors in the rat central nervous system using subtype-specific antibodies

S Schulz, M Händel, M Schreff, H Schmidt… - Journal of Physiology …, 2000 - Elsevier
The cloning of five members of the somatostatin receptor family, sst1-sst5, as well as two
isoforms of the somatostatin receptor 2, sst2A and sst2B, enabled us to generate specific …

Immunohistochemical localization of the somatostatin sst2 (b) receptor splice variant in the rat central nervous system

M Schindler, PPA Humphrey, S Löhrke, E Friauf - Neuroscience, 1999 - Elsevier
Somatostatin is a neuromodulator in the mammalian CNS. To date, genes for at least five
different somatotrophin release inhibiting factor receptors, termed sst1–sst5, have been …

The somatostatin 2A receptor is enriched in migrating neurons during rat and human brain development and stimulates migration and axonal outgrowth

V Le Verche, AM Kaindl, C Verney, Z Csaba… - PLoS …, 2009 - journals.plos.org
The neuropeptide somatostatin has been suggested to play an important role during
neuronal development in addition to its established modulatory impact on neuroendocrine …

Somatostatin increases rat locomotor activity by activating sst2 and sst4 receptors in the striatum and via glutamatergic involvement

S Santis, A Kastellakis, D Kotzamani… - Naunyn-Schmiedeberg's …, 2009 - Springer
The involvement of striatal somatostatin receptors (sst 1, sst 2 and sst 4) in locomotor activity
was investigated. Male Sprague–Dawley rats, 280–350 g, received in the striatum bilateral …

Localization of the somatostatin receptor SST2A in rat brain using a specific anti-peptide antibody

P Dournaud, YZ Gu, A Schonbrunn… - Journal of …, 1996 - Soc Neuroscience
Biological actions of somatostatin are exerted via a family of receptors, for which five genes
recently have been cloned. However, none of these receptor proteins has been visualized …

Involvement of sst2 somatostatin receptor in locomotor, exploratory activity and emotional reactivity in mice

C Viollet, C Vaillend, C Videau… - European Journal of …, 2000 - Wiley Online Library
Somatostatin (SRIF) controls many physiological and pathological processes in the central
nervous system but the respective roles of the five receptor isotypes (sst1–5) that mediate its …

Expression of somatostatin receptor 3 mRNA in the motorneurones of the rat spinal cord, and the sensory neurones of the spinal ganglia

RM Senaris, M Schindler, PPA Humphrey… - Molecular brain …, 1995 - Elsevier
At least five different types of somatostatin receptors (SSTRs): SSTR1-5 have been recently
cloned. Here, we report the distribution of somatostatin receptor 3 (SSTR3) mRNA in spinal …