Virus mechanics under molecular crowding

C Zeng, L Scott, A Malyutin, R Zandi… - The Journal of …, 2021 - ACS Publications
Viruses avoid exposure of the viral genome to harmful agents with the help of a protective
protein shell known as the capsid. A secondary effect of this protective barrier is that …

Relevance of capsid structure in the buckling and maturation of spherical viruses

M Aznar, A Luque, D Reguera - Physical biology, 2012 - iopscience.iop.org
The shape and mechanical properties of viral capsids play an important role in several
biological processes during the virus life cycle. In particular, to become infective, many …

The effect of RNA stiffness on the self-assembly of virus particles

S Li, G Erdemci-Tandogan… - Journal of Physics …, 2017 - iopscience.iop.org
Under many in vitro conditions, some small viruses spontaneously encapsidate a single
stranded (ss) RNA into a protein shell called the capsid. While viral RNAs are found to be …

Intermittency of deformation and the elastic limit of an icosahedral virus under compression

M Hernando-Pérez, C Zeng, MC Miguel, B Dragnea - ACS nano, 2019 - ACS Publications
Viruses undergo mesoscopic morphological changes as they interact with host interfaces
and in response to chemical cues. The dynamics of these changes, over the entire temporal …

Mechanical deformation of spherical viruses with icosahedral symmetry

GA Vliegenthart, G Gompper - Biophysical journal, 2006 - cell.com
Virus capsids and crystalline surfactant vesicles are two examples of self-assembled shells
in the nano-to micrometer size range. Virus capsids are particularly interesting since they …

Structure and energetics guide dynamic behaviour in a T= 3 icosahedral virus capsid

G Shrivastav, S Borkotoky, D Dey, B Singh… - Biophysical …, 2024 - Elsevier
Although virus capsids appear as rigid, symmetric particles in experimentally determined
structures; biochemical studies suggest a significant degree of structural flexibility in the …

How a virus circumvents energy barriers to form symmetric shells

S Panahandeh, S Li, L Marichal, R Leite Rubim… - ACS …, 2020 - ACS Publications
Previous self-assembly experiments on a model icosahedral plant virus have shown that,
under physiological conditions, capsid proteins initially bind to the genome through an en …

Entropic control of particle sizes during viral self-assembly

M Castelnovo, D Muriaux… - New Journal of …, 2013 - iopscience.iop.org
Morphologic diversity is observed across all families of viruses. However, these supra-
molecular assemblies are produced most of the time in a spontaneous way through complex …

Mechanical properties of viral capsids

R Zandi, D Reguera - Physical Review E—Statistical, Nonlinear, and Soft …, 2005 - APS
Viruses are known to tolerate wide ranges of p H and salt conditions and to withstand
internal pressures as high as 100 atmospheres. In this paper we investigate the mechanical …

Virus assembly pathways inside a host cell

S Panahandeh, S Li, B Dragnea, R Zandi - ACS nano, 2022 - ACS Publications
Simple RNA viruses self-assemble spontaneously and encapsulate their genome into a
shell called the capsid. This process is mainly driven by the attractive electrostatics …