Can endothelial glycocalyx be a major morphological substrate in pre-eclampsia?

MM Ziganshina, EL Yarotskaya, NV Bovin… - International journal of …, 2020 - mdpi.com
Today pre-eclampsia (PE) is considered as a disease of various theories; still all of them
agree that endothelial dysfunction is the leading pathogenic factor. Endothelial dysfunction …

Transmission electron microscopy demonstration of reduced endothelial glycocalyx in severe preeclampsia

S Mugerli, D Zupančič, M Lučovnik - Placenta, 2022 - Elsevier
Introduction Endothelial glycocalyx is a carbohydrate-rich layer lining the luminal side of
blood vessels. Its damage was demonstrated in different groups of critically ill patients …

Characterization of vascular patterns associated with endothelial glycocalyx damage in early-and late-onset preeclampsia

MM Ziganshina, KT Muminova, NR Khasbiullina… - Biomedicines, 2022 - mdpi.com
This paper provides an assessment of molecular and functional changes in blood vessels,
and a description of vascular patterns during preeclampsia (PE). Patients with normal …

Early onset preeclampsia is associated with glycocalyx degradation and reduced microvascular perfusion

TL Weissgerber, O Garcia‐Valencia… - Journal of the …, 2019 - Am Heart Assoc
Background The endothelial glycocalyx is a vasoprotective barrier between the blood and
endothelium. We hypothesized that glycocalyx degradation is present in preeclampsia, a …

Circulating concentrations of glycocalyx degradation products in preeclampsia

N Carlberg, C Cluver, C Hesse, SE Thörn… - Frontiers in …, 2022 - frontiersin.org
Background and Objectives: Preeclampsia is a multisystem disorder that affects maternal
endothelium. The glycocalyx lines and protects the endothelial surface. In severe systemic …

Differences of glycocalyx composition in the structural elements of placenta in preeclampsia

GT Sukhikh, MM Ziganshina, NV Nizyaeva… - Placenta, 2016 - Elsevier
Introduction Glycans expressed in the fetal-maternal interface were shown to exert
immunomodulating effects and to mediate interactions between the cells. The aim of this …

The endothelial glycocalyx and neonatal sepsis

A Fatmi, W Saadi, J Beltrán-García… - International Journal of …, 2022 - mdpi.com
Sepsis carries a substantial risk of morbidity and mortality in newborns, especially preterm-
born neonates. Endothelial glycocalyx (eGC) is a carbohydrate-rich layer lining the vascular …

Impairment of endothelial glycocalyx in atherosclerosis and obesity

SJ Ahn, E Le Master, ST Granados, I Levitan - Current Topics in …, 2023 - Elsevier
Endothelial glycocalyx is a negatively charged gel-like layer located on the apical surface of
endothelial cells. It serves as a selective two-way physical barrier between the flowing blood …

Endothelial glycocalyx dimensions are reduced in growing collateral arteries and modulate leucocyte adhesion in arteriogenesis

S Grundmann, SH Schirmer… - Journal of cellular …, 2009 - Wiley Online Library
During collateral artery growth, monocytes adhere to the endothelium and secrete cytokines
from the perivascular space promoting arteriogenesis. Recently, the endothelial glycocalyx …

Regulation and function of endothelial glycocalyx layer in vascular diseases

I Sieve, AK Münster-Kühnel, D Hilfiker-Kleiner - Vascular pharmacology, 2018 - Elsevier
In the vascular system, the endothelial surface layer (ESL) as the inner surface of blood
vessels affects mechanotransduction, vascular permeability, rheology, thrombogenesis, and …