A silica-lipid hybrid (SLH) microcapsule system for oral delivery of poorly water-soluble
drugs is reported for the first time. For the model drug celecoxib (CEL), SLH microcapsules …

We report on the fabrication and characterization of dry hybrid lipid− silica nanoparticle
based microcapsules with an internal porous matrix structure for encapsulation of poorly …

This study is the first to demonstrate in canines the ability of silica-lipid hybrid (SLH)
microparticles to enhance the bioavailability and efficacy of a poorly water-soluble drug after …

We investigate the role of hydrophilic fumed silica in controlling the digestion kinetics of lipid
emulsions, hence further exploring the mechanisms behind the improved oral absorption of …

Silica–lipid–mannitol hybrid (SLMH) microparticles have been developed that were
compressible into high quality tablets suitable for oral dosing and delivery of poorly soluble …

Purpose To investigate the dose linearity of celecoxib (CEL) pharmacokinetics from various
non-lipid and lipid-based formulations; to probe the mechanisms of CEL absorption from a …

We report on a porous silica–lipid hybrid microcapsule (SLH) oral delivery system for
indomethacin fabricated from Pickering emulsion templates, where the drug forms an …

The method of supersaturation for achieving high drug loads in lipid-based formulations is
under exploited and relatively unexplored, especially in the case of solid-state lipid-based …

Newly designed microcapsules (MC) combining a core of solid lipid nanoparticle (SLN) and
a mesoporous silica shell have been developed and explored as oral delivery system of …

Ziprasidone is a poorly water-soluble antipsychotic drug that demonstrates low fasted state
oral bioavailability and a clinically significant two-fold increase in absorption when dosed …