Basal forebrain cholinergic system in the dementias: Vulnerability, resilience, and resistance
C Geula, SR Dunlop, I Ayala, AS Kawles… - Journal of …, 2021 - Wiley Online Library
The basal forebrain cholinergic neurons (BFCN) provide the primary source of cholinergic
innervation of the human cerebral cortex. They are involved in the cognitive processes of …
innervation of the human cerebral cortex. They are involved in the cognitive processes of …
Loss of calbindin-D28K is associated with the full range of tangle pathology within basal forebrain cholinergic neurons in Alzheimer's disease
SS Ahmadian, A Rezvanian, M Peterson… - Neurobiology of …, 2015 - Elsevier
Basal forebrain cholinergic neurons (BFCN) are selectively vulnerable in Alzheimer's
disease (AD). We have shown that most of the BFCN in the human brain contain the calcium …
disease (AD). We have shown that most of the BFCN in the human brain contain the calcium …
New perspectives on the basal forebrain cholinergic system in Alzheimer's disease
AS Berry, TM Harrison - Neuroscience & Biobehavioral Reviews, 2023 - Elsevier
The basal forebrain cholinergic system (BFCS) has long been implicated in age-related
cognitive changes and the pathophysiology of Alzheimer's disease (AD). Limitations of …
cognitive changes and the pathophysiology of Alzheimer's disease (AD). Limitations of …
Atrophy of basal forebrain initiates with tau pathology in individuals at risk for Alzheimer's disease
Evidence suggests that the basal forebrain (BF) cholinergic system degenerates early in the
course of Alzheimer's disease (AD), likely due to the vulnerability of BF cholinergic neurons …
course of Alzheimer's disease (AD), likely due to the vulnerability of BF cholinergic neurons …
[HTML][HTML] Progression of tau pathology in cholinergic Basal forebrain neurons in mild cognitive impairment and Alzheimer's disease
L Vana, NM Kanaan, IC Ugwu, J Wuu… - The American journal of …, 2011 - Elsevier
Tau is a microtubule-associated protein that forms neurofibrillary tangles (NFTs) in the
selective vulnerable long projection neurons of the cholinergic basal forebrain (CBF) in …
selective vulnerable long projection neurons of the cholinergic basal forebrain (CBF) in …
[HTML][HTML] Exploring the pathogenesis of Alzheimer disease in basal forebrain cholinergic neurons: converging insights from alternative hypotheses
XQ Chen, WC Mobley - Frontiers in neuroscience, 2019 - frontiersin.org
Alzheimer disease (AD) represents an oncoming epidemic that without an effective
treatment promises to exact extraordinary financial and emotional burdens. Studies of …
treatment promises to exact extraordinary financial and emotional burdens. Studies of …
Alzheimer's disease and the basal forebrain cholinergic system: relations to β-amyloid peptides, cognition, and treatment strategies
DS Auld, TJ Kornecook, S Bastianetto… - Progress in neurobiology, 2002 - Elsevier
Alzheimer's disease (AD) is the most common form of degenerative dementia and is
characterized by progressive impairment in cognitive function during mid-to late-adult life …
characterized by progressive impairment in cognitive function during mid-to late-adult life …
Loss of calbindin‐D28k from aging human cholinergic basal forebrain: Relation to neuronal loss
C Geula, J Bu, N Nagykery, LFM Scinto… - Journal of …, 2003 - Wiley Online Library
Cholinergic neurons of the basal forebrain (BFCN) are selectively vulnerable in
neurodegenerative disorders of the elderly, particularly in Alzheimer's disease (AD). We …
neurodegenerative disorders of the elderly, particularly in Alzheimer's disease (AD). We …
[HTML][HTML] Longitudinal Alzheimer's degeneration reflects the spatial topography of cholinergic basal forebrain projections
The cholinergic neurons of the basal forebrain (BF) provide virtually all of the brain's cortical
and amygdalar cholinergic input. They are particularly vulnerable to neuropathology in early …
and amygdalar cholinergic input. They are particularly vulnerable to neuropathology in early …
The significance of the cholinergic system in the brain during aging and in Alzheimer's disease
R Schliebs, T Arendt - Journal of neural transmission, 2006 - Springer
Acetylcholine is widely distributed in the nervous system and has been implicated to play a
critical role in cerebral cortical development, cortical activity, controlling cerebral blood flow …
critical role in cerebral cortical development, cortical activity, controlling cerebral blood flow …