Abstract So-called'de-differentiation'of malignant tumors is not identical with'retro-
differentiation'of normal cells, although induction of differentiation of tumor cells seems to be …

In multicellular organisms, internal evolution of individual cells is strictly forbidden
and'evolutional'DNA replication should be performed only by the sexual reproduction …

Publisher Summary This chapter discusses the conversion of malignant cells into normal
ones. In harmony with the current level of knowledge about the nature of malignancy …

Cancer is discussed from a standpoint of a postembryonic differentiation. A differentiation
requires the interaction of an exogenous inductive stimulus with competent precursor cell …

Abstract “Once a cancer cell, always a cancer cell” is classic dogma that arose quite
naturally from observation of the usual intractable course of cancer in human beings. 1 Yet …

Cancers are the most studied yet the least understood of all the diseases of man. Our
ignorance about how to pragmatically control cancers results from our lack of understanding …

Transdifferentiation is a process in which a stable cell's phenotype changes to that of a
distinctly different cell type. It occurs during certain physiological processes and leads to …

In this paper, the genetic aspects of the phenotypic alterations observed in cells after
malignant transformation are discussed. A number of discrete and stable phenotypic …

Abstract Jacob & Monod, and Pitot & Heidelberger have suggested that stable misbehavior
of genetic control systems might underlie cancer. Since their papers, considerable insight …

Publisher Summary This chapter reviews the most representative data accumulated in
recent years that strongly suggest:(1) the resemblance between many cancerous and …