Reactive oxygen species (ROS) are known mediators of intracellular signal cascades.
Excessive production of ROS may lead to oxidative stress, loss of cell function, and cell …

Glutathione peroxidase 4 (Gpx4) is uniquely involved in the detoxification of oxidative
damage to membrane lipids. Our previous studies showed that Gpx4 is essential for mouse …

Reactive oxygen species, such as superoxide and hydrogen peroxide, are generated in all
cells by mitochondrial and enzymatic sources. Left unchecked, these reactive species can …

Numerous studies characterizing the function of glutathione peroxidase 4 (GPx4) have
demonstrated that this selenoenzyme is protective against oxidative stress. Herein, we …

Abstract Glutathione peroxidase 1 (GPx1) is an important cellular antioxidant enzyme that is
found in the cytoplasm and mitochondria of mammalian cells. Like most selenoenzymes, it …

Maintaining the balance of a cell's redox function is key to determining cell fate. In the critical
redox system of mammalian cells, glutathione peroxidase (GPX) is the most prominent …

BACKGROUND: With increasing evidence that hydroperoxides are not only toxic but rather
exert essential physiological functions, also hydroperoxide removing enzymes have to be re …

Abstract Glutathione peroxidase-1 (GPX1) represents the first identified mammalian
selenoprotein, and our understanding in the metabolic regulation and function of this …

The redox enzyme phospholipid hydroperoxide glutathione peroxidase (PHGPx) has
emerged as one of the most significant selenoenzymes in mammals, corroborated by early …

Phospholipid hydroperoxide glutathione peroxidase (PHGPx) is synthesized as a long form
(L-form; 23 kDa) and a short form (S-form; 20 kDa). The L-form contains a leader sequence …