In vitro and in vivo anticancer effects of Lithospermum erythrorhizon extract on B16F10 murine melanoma

S Rajasekar, C Park, S Park, YH Park, ST Kim… - Journal of …, 2012 - Elsevier
ETHNOPHARMACOLOGICAL RELEVANCE: Lithospermum erythrorhizon has long been
used in traditional Asian medicine for the treatment of diseases including skin cancer. In this …

Shikonin inhibits proliferation of melanoma cells by MAPK pathway-mediated induction of apoptosis

JH Lee, SH Han, YM Kim, SH Kim, ES Yoo… - Bioscience …, 2021 - portlandpress.com
Shikonin, a natural product isolated from the roots of Lithospermum erythrorhizon, exhibits
pharmacological effects against inflammation, ulcers, infections, and tumors. In the present …

Acetylshikonin inhibits growth of oral squamous cell carcinoma by inducing apoptosis

JH Lee, HR Park, YW Choi - Archives of Oral Biology, 2016 - Elsevier
Objectives Recently, shikonin derivatives from Lithospermum erythrorhizon have been
suggested as potential chemotherapeutic agents against numerous types of cancers in …

Shikonin induces apoptosis through reactive oxygen species/extracellular signal-regulated kinase pathway in osteosarcoma cells

IC Chang, YJ Huang, TI Chiang, CW Yeh… - Biological and …, 2010 - jstage.jst.go.jp
Shikonin, a major ingredient in the Chinese traditional herb Lithospermum erythrorhixon,
exhibits multiple biological functions including antimicrobial, anti-inflammatory, and …

Acetylshikonin induces apoptosis of human osteosarcoma U2OS cells by triggering ROS-dependent multiple signal pathways

HS Cha, HK Lee, SH Park, MJ Nam - Toxicology in Vitro, 2023 - Elsevier
Acetylshikonin a natural compound isolated from the root of Lithospermum erythrorhizon
and one of the shikonin derivatives which possess promising anticarcinogenic ability. In this …

Novel multiple apoptotic mechanism of shikonin in human glioma cells

CH Chen, ML Lin, PL Ong, JT Yang - Annals of surgical oncology, 2012 - Springer
Background Shikonin is the main naphthoquinone compound of the root of Lithospermum
erythrorhizon. Our previous study demonstrated that shikonin possesses anticancer activity …

Effect of shikonin on human breast cancer cells proliferation and apoptosis in vitro

Y Hou, T Guo, C Wu, X He, M Zhao - Yakugaku Zasshi, 2006 - jstage.jst.go.jp
Shikonin, isolated from the plant Lithospermum erythrorhizon Sieb. Et Zucc, has been
reported to induce apoptosis in several tumor cells. However, such eŠect of shikonin on …

Growth inhibitory and apoptosis inducing by effects of total flavonoids from Lysimachia clethroides Duby in human chronic myeloid leukemia K562 cells

Y Liu, L Tang, Z Liang, B You, S Yang - Journal of ethnopharmacology, 2010 - Elsevier
ETHNOPHARMACOLOGICAL RELEVANCE: Lysimachia clethroides Duby is a traditional
Chinese medicinal herb has been used in China to treat edema, jaundice diseases …

Antineoplastic effects of honokiol on melanoma

R Guillermo-Lagae, S Santha… - BioMed research …, 2017 - Wiley Online Library
Honokiol, a plant lignan has been shown to have antineoplastic effects against
nonmelanoma skin cancer developments in mice. In this study, antineoplastic effects of …

Shikonin Derivatives Protect Immune Organs from Damage and Promote Immune Responses In Vivo in Tumour‐bearing Mice

S Long, Y GuangZhi, G BaoJie, X Wei… - Phytotherapy …, 2012 - Wiley Online Library
Shikonin, a major component of Lithospermum erythrorhizon and Arnebia euchroma,
exhibits antiinflammatory, immunomodulatory and antitumour activities. Although many …