Objective Systemic sclerosis (SSc) is a multifactorial autoimmune fibrotic disorder involving
complex rewiring of cell‐intrinsic and cell‐extrinsic signaling coexpression networks …

Objectives Treatment of patients with systemic sclerosis (SSc) can be challenging because
of clinical heterogeneity. Integration of genome-scale transcriptomic profiling for patients …

Systemic sclerosis (SSc) is a rare autoimmune disease with the highest case-fatality rate of
all connective tissue diseases. Current efforts to determine patient response to a given …

Objectives Although T cells have been implicated in the pathogenesis of systemic sclerosis
(SSc), a comprehensive study of T-cell-mediated immune responses in the affected skin of …

Systemic sclerosis (SSc) is a rare systemic autoimmune disease characterized by skin and
organ fibrosis. The pathogenesis of SSc and its progression are poorly understood. The SSc …

Objective Immunological disturbances have been reported in systemic sclerosis (SSc). This
study assessed the transcriptome disturbances in immune cell subsets in SSc and …

Localized scleroderma (LS) is an autoimmune disease with both inflammatory and fibrotic
components causing an abnormal deposition of collagen in the skin and underlying tissue …

Objectives Determine relationships between skin gene expression and systemic sclerosis
(SSc) clinical disease features, and changes in skin gene expression over time. Methods A …

Pathophysiology of systemic sclerosis (SSc, Scleroderma), an autoimmune rheumatic
disease, comprises of mechanisms that drive vasculopathy, inflammation and fibrosis …

Genome-wide expression profiling in systemic sclerosis (SSc) has identified four
'intrinsic'subsets of disease (fibroproliferative, inflammatory, limited, and normal-like), each …