Ultraviolet light has been linked with the development of human skin cancers. Such cancers
often exhibit mutations in the p53 tumor suppressor gene. Ligation-mediated polymerase …

The repair of cyclobutane pyrimidine dimers (CPDs), DNA lesions induced by ultraviolet
light, was studied at nucleotide resolution. Human fibroblasts were irradiated with ultraviolet …

The frequency of UV-induced mutations at specific nucleotides along the lacI gene of
Escherichia coli varies by as much as 80-fold1. The spectrum of mutations to amber, ochre …

UV-induced mutations in the p53 tumor suppressor gene play an essential role in skin
cancer development. We report here that such mutations can be detected in UV-irradiated …

Ultraviolet light has been identified as the major carcinogen in skin cancer and the p53
tumor suppressor gene is a major target for UV‐induced mutations. The mutations are …

The different ultraviolet (UV) wavelength components, UVA (320–400nm), UVB (280–
320nm), and UVC (200–280nm), have distinct mutagenic properties. A hallmark of UVC and …

EXCISION repair plays a vital role in the recovery of human cells from ultraviolet irradiation1,
but it does not remove all lesions from DNA, even when they are as potent as cyclobutane …

Exposure of normal human skin in vivo to ultraviolet irradiation at wavelengths shorter than
320 nanometers stimulated an unscheduled DNA synthesis in all of the cell layers of the …

Exposure to UV radiation has long been associated with the development of skin cancers.
To identify the molecular targets in UV carcinogenesis, we analyzed 11 UV-induced murine …

SKIN fibroblasts derived from patients with the autosomal recessive disease xeroderma
pigmentosum are defective in excision repair of photodamage induced by short wavelength …