Molecular dynamics simulations reveal ligand-controlled positioning of a peripheral protein complex in membranes
SM Ryckbosch, PA Wender, VS Pande - Nature communications, 2017 - nature.com
Bryostatin is in clinical trials for Alzheimer's disease, cancer, and HIV/AIDS eradication. It
binds to protein kinase C competitively with diacylglycerol, the endogenous protein kinase C …
binds to protein kinase C competitively with diacylglycerol, the endogenous protein kinase C …
Interactions of protein kinase C-α C1A and C1B domains with membranes: a combined computational and experimental study
Protein kinase C-α (PKCα) has been studied widely as a paradigm for conventional PKCs,
with two C1 domains (C1A and C1B) being important for the regulation and function of the …
with two C1 domains (C1A and C1B) being important for the regulation and function of the …
Dynamics and membrane interactions of protein kinase C
TI Igumenova - Biochemistry, 2015 - ACS Publications
Protein kinase C (PKC) is a family of Ser/Thr kinases that regulate a multitude of cellular
processes through participation in the phosphoinositide signaling pathway. Significant …
processes through participation in the phosphoinositide signaling pathway. Significant …
The C1 and C2 domains of protein kinase C are independent membrane targeting modules, with specificity for phosphatidylserine conferred by the C1 domain
JE Johnson, J Giorgione, AC Newton - Biochemistry, 2000 - ACS Publications
Protein kinase C is specifically activated by binding two membrane lipids: the second
messenger, diacylglycerol, and the amino phospholipid, phosphatidylserine. This binding …
messenger, diacylglycerol, and the amino phospholipid, phosphatidylserine. This binding …
Contribution of the C1A and C1B domains to the membrane interaction of protein kinase C
J Giorgione, M Hysell, DF Harvey, AC Newton - Biochemistry, 2003 - ACS Publications
The hallmark for protein kinase C activation is its “translocation” to membranes following
generation of lipid second messengers. This translocation is mediated by the C1 and C2 …
generation of lipid second messengers. This translocation is mediated by the C1 and C2 …
REDOR NMR reveals multiple conformers for a protein kinase C ligand in a membrane environment
H Yang, D Staveness, SM Ryckbosch… - ACS Central …, 2018 - ACS Publications
Bryostatin 1 (henceforth bryostatin) is in clinical trials for the treatment of Alzheimer's disease
and for HIV/AIDS eradication. It is also a preclinical lead for cancer immunotherapy and …
and for HIV/AIDS eradication. It is also a preclinical lead for cancer immunotherapy and …
Electrostatic and hydrophobic interactions differentially tune membrane binding kinetics of the C2 domain of protein kinase Cα
The cellular activation of conventional protein kinase C (PKC) isozymes is initiated by the
binding of their C2 domains to membranes in response to elevations in intracellular Ca 2+ …
binding of their C2 domains to membranes in response to elevations in intracellular Ca 2+ …
Regulation of protein kinase C βII by its C2 domain
AS Edwards, AC Newton - Biochemistry, 1997 - ACS Publications
The C2 domain serves as a membrane-targeting module in a diverse group of proteins that
includes the conventional protein kinase Cs. This work examines the mechanism by which …
includes the conventional protein kinase Cs. This work examines the mechanism by which …
Structural basis of binding of high-affinity ligands to protein kinase C: prediction of the binding modes through a new molecular dynamics method and evaluation by …
Y Pak, IJ Enyedy, J Varady, JW Kung… - Journal of medicinal …, 2001 - ACS Publications
The structural basis of protein kinase C (PKC) binding to several classes of high-affinity
ligands has been investigated through complementary computational and experimental …
ligands has been investigated through complementary computational and experimental …
C2 domain of protein kinase Cα: elucidation of the membrane docking surface by site-directed fluorescence and spin labeling
SC Kohout, S Corbalán-García… - Biochemistry, 2003 - ACS Publications
The C2 domain is a conserved signaling motif that triggers membrane docking in a Ca2+-
dependent manner, but the membrane docking surfaces of many C2 domains have not yet …
dependent manner, but the membrane docking surfaces of many C2 domains have not yet …