Phasic versus tonic dopamine release and the modulation of dopamine system responsivity: a hypothesis for the etiology of schizophrenia
AA Grace - Neuroscience, 1991 - Elsevier
A novel mechanism for regulating dopamine activity in subcortical sites and its possible
relevance to schizophrenia is proposed. This hypothesis is based on the regulation of …
relevance to schizophrenia is proposed. This hypothesis is based on the regulation of …
The regulation of subcortical dopamine systems by the prefrontal cortex: interactions of central dopamine systems and the pathogenesis of schizophrenia
AY Deutch - Advances in Neuroscience and Schizophrenia, 1992 - Springer
A recent hypothesis of the pathogenesis of schizophrenia posits a developmentally-specific
dysfunction of the dopaminergic innervation of the prefrontal cortex (PFC; Weinberger, 1987; …
dysfunction of the dopaminergic innervation of the prefrontal cortex (PFC; Weinberger, 1987; …
Dopamine in schizophrenia: a review and reconceptualization.
KL Davis, RS Kahn, G Ko… - The American journal of …, 1991 - europepmc.org
Objective The initial hypothesis that schizophrenia is a manifestation of hyperdopaminergia
has recently been faulted. However, several new findings suggest that abnormal, although …
has recently been faulted. However, several new findings suggest that abnormal, although …
An integrative perspective on the role of dopamine in schizophrenia
We propose that schizophrenia involves a combination of decreased phasic dopamine
responses for relevant stimuli and increased spontaneous phasic dopamine release. Using …
responses for relevant stimuli and increased spontaneous phasic dopamine release. Using …
The regulation of forebrain dopamine transmission: relevance to the pathophysiology and psychopathology of schizophrenia
H Moore, AR West, AA Grace - Biological psychiatry, 1999 - Elsevier
Since the discovery that the therapeutic efficacy of antipsychotic drugs was significantly
correlated to their ability to block dopamine D2 receptors, abnormal dopamine transmission …
correlated to their ability to block dopamine D2 receptors, abnormal dopamine transmission …
Dopamine and the diseased brain
Dysfunction of central dopaminergic neurotransmission has been implicated in a series of
neuropsychiatric disorders, including Tourette's syndrome, schizophrenia, and drug and …
neuropsychiatric disorders, including Tourette's syndrome, schizophrenia, and drug and …
Dopaminergic mechanisms in the pathogenesis of schizophrenia1
M Goldstein, AY Deutch - The FASEB Journal, 1992 - Wiley Online Library
The dopamine hypothesis of schizophrenia has been the dominant theoretical construction
guiding research and treatment of the schizophrenic disorders over the past generation. This …
guiding research and treatment of the schizophrenic disorders over the past generation. This …
Developing a neuronal model for the pathophysiology of schizophrenia based on the nature of electrophysiological actions of dopamine in the prefrontal cortex
CR Yang, JK Seamans, N Gorelova - Neuropsychopharmacology, 1999 - Elsevier
This review covers some recent findings of the electrophysiological mechanisms through
which mesocortical dopamine modulates prefrontal cortical neurons. Dopamine has been …
which mesocortical dopamine modulates prefrontal cortical neurons. Dopamine has been …
The dopamine hypothesis of schizophrenia: limbic interactions with serotonin and norepinephrine
JN Joyce - Psychopharmacology, 1993 - Springer
The “dopamine hypothesis” of schizophrenia has been the predominant guiding theoretical
construct for driving studies of the neurobiology of schizophrenia. There has, however, been …
construct for driving studies of the neurobiology of schizophrenia. There has, however, been …
The Yin and Yang of dopamine release: a new perspective
Dopamine has undergone extensive investigation due to its known involvement in a number
of neurological and psychiatric disorders. In particular, studies into pathological conditions …
of neurological and psychiatric disorders. In particular, studies into pathological conditions …