Screening of ToxCast chemicals responsible for human adverse outcomes with exposure to ambient air

L Qiao, L Gao, D Huang, Y Liu, C Xu, D Li… - … Science & Technology, 2022 - ACS Publications
Air pollution poses a major threat to global public health. Although there have been a few
investigations into the relationships between organic pollutants and adverse outcomes, the …

A toxicogenomic comparison of primary and photochemically altered air pollutant mixtures

JE Rager, K Lichtveld, S Ebersviller… - Environmental …, 2011 - ehp.niehs.nih.gov
Background: Air pollution contributes significantly to global increases in mortality,
particularly within urban environments. Limited knowledge exists on the mechanisms …

Human indoor exposome of chemicals in dust and risk prioritization using EPA's ToxCast database

T Dong, Y Zhang, S Jia, H Shang, W Fang… - … science & technology, 2019 - ACS Publications
Humans spend most of their time indoors and thus have long-term exposure to chemicals.
Dust is a sink for most indoor chemicals, and its ingestion is an important pathway for …

Improving the human hazard characterization of chemicals: a Tox21 update

RR Tice, CP Austin, RJ Kavlock… - Environmental health …, 2013 - ehp.niehs.nih.gov
Background: In 2008, the National Institute of Environmental Health Sciences/National
Toxicology Program, the US Environmental Protection Agency's National Center for …

Exploring the occurrence and temporal variation of ToxCast chemicals in fine particulate matter using suspect screening strategy

Y Lin, J Yang, Q Fu, T Ruan… - Environmental science & …, 2019 - ACS Publications
Existence of emerging contaminants in the environment is of great importance for health risk
assessment. The consensus on categories and numbers of the emerging contaminants in …

Leveraging the comparative toxicogenomics database to fill in knowledge gaps for environmental health: a test case for air pollution-induced cardiovascular disease

AP Davis, TC Wiegers, CJ Grondin… - Toxicological …, 2020 - academic.oup.com
Environmental health studies relate how exposures (eg, chemicals) affect human health and
disease; however, in most cases, the molecular and biological mechanisms connecting an …

[HTML][HTML] Exposure and toxicity characterization of chemical emissions and chemicals in products: global recommendations and implementation in USEtox

P Fantke, WA Chiu, L Aylward, R Judson… - The international journal …, 2021 - Springer
Purpose Reducing chemical pressure on human and environmental health is an integral
part of the global sustainability agenda. Guidelines for deriving globally applicable, life cycle …

[HTML][HTML] Comment on “On the Utility of ToxCast™ and ToxPi as Methods for Identifying New Obesogens”

KA Houck, RS Judson, TB Knudsen… - Environmental …, 2017 - ehp.niehs.nih.gov
Janesick and colleagues recently published an evaluation of the utility of ToxCast™ and
Tox21 bioactivity data for predicting PPARγ activation and induction of adipogenesis. As …

[HTML][HTML] An annotation database for chemicals of emerging concern in exposome research

J Meijer, M Lamoree, T Hamers, JP Antignac… - Environment …, 2021 - Elsevier
Abstract Background Chemicals of Emerging Concern (CECs) include a very wide group of
chemicals that are suspected to be responsible for adverse effects on health, but for which …

The exposome and toxicology: a win–win collaboration

R Barouki, K Audouze, C Becker, L Blaha… - Toxicological …, 2022 - academic.oup.com
The development of the exposome concept has been one of the hallmarks of environmental
and health research for the last decade. The exposome encompasses the life course …