Pituitary adenylyl cyclase activating polypeptide (PACAP) was originally isolated from the
hypothalamus and found to stimulate adenylyl cyclase in the pituitary. Later studies showed …

Pituitary adenylate cyclase-activating polypeptide (PACAP) has been conserved remarkably
during evolution and is widely expressed in the nervous system across phyla. PACAP has …

Pituitary adenylyl cyclase activating polypeptide (PACAP) and its receptors (PAC1, VPAC1,
and VPAC2) are localized in brain regions implicated in stress response, reward seeking …

Pituitary adenylate cyclase-activating polypeptide (PACAP) was discovered thirty years ago,
but its role in eating and drug use disorders has only recently begun to be investigated. The …

Pituitary adenylate cyclase-activating polypeptide (PACAP) is a highly conserved pleiotropic
neuropeptide that functions as a neurotransmitter, neuromodulator and neurotrophic factor …

Background Major depressive disorder (MDD) is a chronic, life-threatening psychiatric
condition characterized by depressed mood, psychomotor alterations, and a markedly …

Rationale Anxiety disorders are the most common mental disorders in the USA.
Characterized by feelings of uncontrollable apprehension, they are accompanied by …

Rationale The neuropeptide pituitary adenylyl cyclase-activating peptide (PACAP) and its
receptors (PAC1 and VPAC2) are expressed in the ventral tegmental area and nucleus …

Anxiety disorders represent the most common mental disturbances in the world, and they
are characterized by an abnormal response to stress. Pituitary adenylate cyclase-activating …

Several lines of evidence suggest that pituitary adenylate cyclase-activating polypeptide
(PACAP) is a neuropeptide playing an important role as a neuromodulator. It has been …