Posterior corneoscleral limbus: Architecture, stem cells, and clinical implications

GHF Yam, S Pi, Y Du, JS Mehta - Progress in Retinal and Eye Research, 2023 - Elsevier
The limbus is a transition from the cornea to conjunctiva and sclera. In human eyes, this thin
strip has a rich variation of tissue structures and composition, typifying a change from scleral …

The limbal epithelium of the eye–a review of limbal stem cell biology, disease and treatment

C Osei‐Bempong, FC Figueiredo, M Lako - Bioessays, 2013 - Wiley Online Library
The limbus is a narrow band of tissue that encircles the cornea, the transparent 'window'into
the eye. The outermost layer of the cornea is the epithelium, which is necessary for clear …

[HTML][HTML] Limbal stem cells in review

M Ebrahimi, E Taghi-Abadi… - Journal of ophthalmic & …, 2009 - ncbi.nlm.nih.gov
The ocular surface consists of two distinct types of epithelial cells; conjunctival and corneal.
Although anatomically continuous, these epithelia comprise two distinct cell populations …

[HTML][HTML] Corneoscleral limbus in glaucoma patients: in vivo confocal microscopy and immunocytological study

R Mastropasqua, L Agnifili, V Fasanella… - … & visual science, 2015 - tvst.arvojournals.org
Purpose.: To investigate morphologic changes of the corneoscleral limbus in glaucoma
patients using laser scanning confocal microscopy (LSCM) and impression cytology (IC) …

The corneal epithelial stem cell niche

MA Stepp, JD Zieske - The ocular surface, 2005 - Elsevier
In recent years, it has become generally accepted that the corneal epithelial stem cells are
localized in the basal cell layer of the limbal epithelium. However, a number of questions …

The role of limbal stem cells in corneal epithelial maintenance: testing the dogma

HS Dua, A Miri, T Alomar, AM Yeung, DG Said - Ophthalmology, 2009 - Elsevier
OBJECTIVE: To study and characterize the epithelial cells in patients with a central “island”
of normal epithelial cells surrounded with 360° of clinically apparent limbal stem cell (SC) …

Concept and application of limbal stem cells

SCG Tseng - Eye, 1989 - nature.com
Cumulative reported evidence indicates that some fraction of limbal basal epithelial cells are
the stem cells for corneal epithelial cell proliferation and differentiation. Limbal epithelium is …

Niche regulation of corneal epithelial stem cells at the limbus

W Li, Y Hayashida, YT Chen, SCG Tseng - Cell research, 2007 - nature.com
Among all adult somatic stem cells, those of the corneal epithelium are unique in their
exclusive location in a defined limbal structure termed Palisades of Vogt. As a result …

Current and emerging therapies for limbal stem cell deficiency

AM Elhusseiny, M Soleimani, TK Eleiwa… - Stem cells …, 2022 - academic.oup.com
The corneal epithelium serves to protect the underlying cornea from the external
environment and is essential for corneal transparency and optimal visual function …

Corneal epithelial stem cells–physiology, pathophysiology and therapeutic options

Y Ruan, S Jiang, A Musayeva, N Pfeiffer, A Gericke - Cells, 2021 - mdpi.com
In the human cornea, regeneration of the epithelium is regulated by the stem cell reservoir of
the limbus, which is the marginal region of the cornea representing the anatomical and …