Gynecological oncology is an alarming global health agenda within the present mortality
statistics. The most well-explored, precise epigenetic alterations are DNA methylation and …

Breast, ovarian and endometrial cancers cause significant morbidity and mortality. Despite
the presence of existing screening, diagnostic and treatment modalities, they continue to …

Patients diagnosed with epithelial ovarian cancer (OC) have a 5-year survival rate of 49%.
For early-stage disease, the 5-year survival rate is above 90%. However, advanced-stage …

Purpose Uterine neoplasms comprise a broad spectrum of lesions, some of which may pose
a diagnostic challenge even to experienced pathologists. Recently, genome-wide DNA …

Objectives DNA methylation occurs early in carcinogenesis and differ among cancer
subtypes, suggest that these biomarkers might be useful in early detection and in defining …

Abstract Introduction: Ovarian cancer (OC), often diagnosed at an advanced stage, lacks
effective screening strategy. It is the most lethal gynecological cancer, with a 5-year survival …

Carcinogenesis is accompanied by widespread DNA methylation changes within the cell.
These changes are characterized by a globally hypomethylated genome with focal …

DNA methylation is a fundamental mechanism of epigenetic control in cells and its
dysregulation is strongly implicated in cancer development. Cancers possess an extensively …

Cellular DNA undergoes profound changes in methylation during cancer development, with
hypermethylation occurring in specific gene promoters, amidst a backdrop of generalized …

Objective: DNA methylation is an early event in endometrial cancer (EC) development and
may have utility in early detection. We conducted a whole methylome search followed by …