The characteristic maximum lifespan varies enormously across animal species from a few
hours to hundreds of years. This argues that maximum lifespan, and the ageing process that …

Alzheimer's disease (AD) is a chronic multifactorial and complex neuro-degenerative
disorder characterized by memory impairment and the loss of cognitive ability, which is a …

The amyloid hypothesis, the assumption that beta-amyloid toxicity is the primary cause of
neuronal and synaptic loss, has been the mainstream research concept in Alzheimer's …

Contemporary studies on aging and longevity have largely overlooked the role that
adaptation plays in lifespan variation across species. Emerging evidence indicates that the …

Due to their postmitotic status, the potential for neurons to undergo senescence has
historically received little attention. This lack of attention has extended to some non …

Alzheimer's disease is one of the most devastating neurodegenerative diseases. The exact
cause of the disease is still not known although many scientists believe in the beta amyloid …

Objective We explore here a novel model for amyloidogenesis in Alzheimer's disease (AD).
This new perspective on AD amyloidosis seeks to provide a rational framework for …

In this paper we present cellular senescence as the ultimate driver of the aging process, as a
“causal nexus” that bridges microscopic subcellular damage with the phenotypic …

Alzheimer's disease (AD) is a leading cause of dementia among elderly. Yet, its etiology
remains largely unclear. In this review, we summarize studies that associate systemic …

Alzheimer's disease (AD) represents an urgent public health mandate. AD is no longer
considered a neural-centric disease; rather, a plethora of recent studies strongly implicate a …