Overcoming tumor resistance mechanisms in CAR-NK cell therapy
A Valeri, A García-Ortiz, E Castellano… - Frontiers in …, 2022 - frontiersin.org
Despite the impressive results of autologous CAR-T cell therapy in refractory B
lymphoproliferative diseases, CAR-NK immunotherapy emerges as a safer, faster, and cost …
lymphoproliferative diseases, CAR-NK immunotherapy emerges as a safer, faster, and cost …
Novel insights in CAR-NK cells beyond CAR-T cell technology; promising advantages
CAR-T (chimeric antigen receptor T cell) technology, which has recently showed successful
results in the treatment of hematological tumors, has been the focus of attention as one of …
results in the treatment of hematological tumors, has been the focus of attention as one of …
CAR-NK cells in the treatment of solid tumors
E Wrona, M Borowiec, P Potemski - International journal of molecular …, 2021 - mdpi.com
CAR-T (chimeric antigen receptor T) cells have emerged as a milestone in the treatment of
patients with refractory B-cell neoplasms. However, despite having unprecedented efficacy …
patients with refractory B-cell neoplasms. However, despite having unprecedented efficacy …
CAR‐NK cell in cancer immunotherapy; A promising frontier
F Marofi, OF Abdul‐Rasheed, HS Rahman… - Cancer …, 2021 - Wiley Online Library
Chimeric antigen receptors (CARs) have a unique facet of synthetic biology and offer a
paradigm shift in personalized medicine as they can use and redirect the patient's immune …
paradigm shift in personalized medicine as they can use and redirect the patient's immune …
CAR NK cell therapy in hematologic malignancies and solid tumors; obstacles and strategies to overcome the challenges
Adoptive cell treatment (ACT) utilizing chimeric antigen receptors (CAR) diverts the
specificity of safe cells against a target-specific antigen and portrays exceptional potential for …
specificity of safe cells against a target-specific antigen and portrays exceptional potential for …
CAR-cell therapy in the era of solid tumor treatment: current challenges and emerging therapeutic advances
In the last decade, Chimeric Antigen Receptor (CAR)-T cell therapy has emerged as a
promising immunotherapeutic approach to fight cancers. This approach consists of …
promising immunotherapeutic approach to fight cancers. This approach consists of …
Taking lessons from CAR-T cells and going beyond: tailoring design and signaling for CAR-NK cells in cancer therapy
Cancer immunotherapies utilize the capabilities of the immune system to efficiently target
malignant cells. In recent years, chimeric antigen receptor (CAR) equipped T cells showed …
malignant cells. In recent years, chimeric antigen receptor (CAR) equipped T cells showed …
[HTML][HTML] NK cells enhance CAR-T cell antitumor efficacy by enhancing immune/tumor cells cluster formation and improving CAR-T cell fitness
M Bachiller, L Perez-Amill, AM Battram… - … for immunotherapy of …, 2021 - ncbi.nlm.nih.gov
Background Chimeric antigen receptor (CAR)-T cell immunotherapy has modified the
concept of treatment in hematological malignancies. In comparison with pediatric patients …
concept of treatment in hematological malignancies. In comparison with pediatric patients …
CAR-NK cells: from natural basis to design for kill
Chimeric antigen receptors (CARs) are fusion proteins with an extracellular antigen
recognition domain and numerous intracellular signaling domains that have been …
recognition domain and numerous intracellular signaling domains that have been …
You have got a fast CAR: chimeric antigen receptor NK cells in cancer therapy
A Pfefferle, ND Huntington - Cancers, 2020 - mdpi.com
The clinical success stories of chimeric antigen receptor (CAR)-T cell therapy against B-cell
malignancies have contributed to immunotherapy being at the forefront of cancer therapy …
malignancies have contributed to immunotherapy being at the forefront of cancer therapy …