Capsaicin-sensitive peptidergic sensory nerves mediate triple actions: besides transmitting
sensory and pain signals to the central nervous system (afferent function), they also have …

Neuropeptides released from the activated peripheral terminals of capsaicin-sensitive
subpopulation of sensory neurons exert local efferent function besides the classical afferent …

Abstract Purpose of Review Neuropathic pain (NP) has been ubiquitously characterized by
lesion and its linked somatosensory system either the central nervous system (CNS) or …

Pain has been considered as a concept of sensation that we feel as a reaction to the
stimulus of our surrounding, putting us in harm's way and acting as a form of defense …

Pain is the most frequent cause triggering patients to visit a physician. The worldwide
incidence of chronic pain is in the range of 20% of adults, and chronic pain conditions are …

Pain is estimated to affect more than 20% of the global population, imposing incalculable
health and economic burdens. Effective pain management is crucial for individuals suffering …

Inflammatory pain refers to the increased sensitivity of perception and emotional response to
noxious stimuli, that arises from an inflammatory reaction associated with tissue damage …

The mechanisms of chronic pain are complex, and genetic factors play an essential role in
the development of chronic pain. Neuropathic pain (NP) and inflammatory pain (IP) are two …

Chronic pain leading to a reduced quality of life is one of the most important health problems
worldwide. It has been estimated that 10% of adults are diagnosed with chronic pain each …

Neuropathic pain often leads to negative emotions, which in turn can enhance the sensation
of pain. This study aimed to investigate the molecular mechanisms mediating neuropathic …