Serum testosterone (TS) levels decrease with aging in both humans and rodents. Using the
rat as a model system, it was found that age-related reductions in serum TS were not due to …

This article summarizes a talk on Leydig cell aging presented at the 1999 Annual Meeting of
the Society for the Study of Reproduction. In the Brown Norway rat, serum testosterone …

Leydig cell testosterone (T) production is reduced with age, resulting in reduced serum T
levels (hypogonadism). A number of cellular changes have been identified in the …

Male aging is accompanied by reduced testosterone production by the Leydig cells, the
testosterone-producing cells of the testis. The mechanism by which this occurs is unknown …

In males, serum testosterone levels decline with advancing age. Though part of a complex
process, this age-related decline in testosterone appears to occur, in part, due to a …

Previous studies have demonstrated that Leydig cell testosterone production diminishes
with age in Brown Norway rats. The objective of the studies presented herein was to test the …

Previous studies have shown that the capacity of Leydig cells from aged (21‐24‐month‐old)
Brown Norway rats to produce testosterone is reduced from young (4‐month‐old) levels …

As men age, serum testosterone (T) levels decline, whereas serum luteinizing hormone (LH)
levels increase somewhat or remain unchanged. Age‐related reductions in T levels may be …

Abstract Aging in Brown Norway rats is associated with reduced Leydig cell T production. To
address the mechanism by which aging Leydig cells become steroidogenically …

Previous studies have shown that testosterone production by the Leydig cells of aged Brown
Norway rats is reduced from the relatively high levels produced by Leydig cells of young rats …