New series of thiazolyl-pyrazoline derivatives (7a–7d, 10a–10d and 13a–13f) have been
synthesised and assessed for their potential EGFR and VEGFR-2 inhibitory activities …

Introduction Epidermal growth factor receptor (EGFR) regulates several cell functions which
include cell growth, survival, multiplication, differentiation, and apoptosis. Currently, EGFR …

EGFR and VEGFR-2 represent promising targets for cancer treatment as they are very
important in tumor development as well as in angiogenesis and metastasis. In this work, 6 …

Aim: Design and synthesis of thienopyrimidine derivatives as dual EGFR and VEGFR-2
inhibitors. Material and methods: A series of novel 6, 7, 8, 9-tetrahydro-5 H-cyclohepta [4, 5] …

Abstract Quinoline derivatives 2, 3, quinolinyl based pyrazolines 4a, b, 5 and quinolinyl
pyrazolinyl thiazole hybrids 6a-d, 7a-c and 8a-d were synthesized and screened for their …

The present study describes the synthesis of 6-bromo-2-(pyridin-3-yl)-4-substituted
quinazolines starting from 4-chloro derivative VI via the reaction with either phenolic …

A novel series of benzothiazole-based derivatives linked to various amino acids and their
corresponding ethyl ester analogues were prepared and were initially evaluated for their …

A new series of 2-aminobenzothiazole hybrids linked to thiazolidine-2, 4-dione 4a–e, 1, 3, 4-
thiadiazole aryl urea 6a–d, and cyanothiouracil moieties 8a–d was synthesised. The in vitro …

In this study, novel VEGFR-2-targeting thiazolidine-2, 4-dione derivatives with potential
anticancer properties were designed and synthesized. The ability of the designed …

Sixteen novel quinazoline-based derivatives were designed and synthesized via
modification of the VEGFR-2 reported inhibitor 7 in order to increase the binding affinity of …