Motivation: Recent improvements in high-throughput Mass Spectrometry (MS) technology
have expedited genome-wide discovery of protein–protein interactions by providing a …

Studying protein-protein interaction networks provide key evidence for the underlying
molecular mechanisms. Mass spectrometry-based proteomic approaches have been …

Background Identifying all protein-protein interactions in an organism is a major objective of
proteomics. A related goal is to know which protein pairs are present in the same protein …

The biological significance of protein interactions, their method of generation and reliability
is briefly reviewed. Protein interaction networks adopt a scale-free topology that explains …

Analysis of protein interaction networks and protein complexes using affinity purification and
mass spectrometry (AP/MS) is among most commonly used and successful applications of …

Background Most proteins form macromolecular complexes to perform their biological
functions. However, experimentally determined protein complex data, especially of those …

Protein-protein interactions play important roles in nearly all events that take place in a cell.
High-throughput experimental techniques enable the study of protein-protein interactions at …

Protein-protein interactions are important for nearly all biological processes, and it is known
that aberrant protein-protein interactions can lead to human disease and cancer. Recent …

The systematic characterization of the whole interactomes of different model organisms has
revealed that the eukaryotic proteome is highly interconnected. Therefore, biological …

The spectacular heterogeneity of a complex protein mixture from biological samples
becomes even more difficult to tackle when one's attention is shifted towards different protein …