The mechanism of the abnormal increase in extracellular glutamate concentration in the
hippocampus induced with 100mM KCl in zinc deficiency is unknown. In the present study …

Zinc homeostasis in the brain is affected by dietary zinc deficiency, and its alteration may
cause brain dysfunctions. On the basis of the previous evidence that hippocampal zinc was …

Abstract Yokukansan (TJ-54), a herbal medicine, has been used as a cure for insomnia and
irritability in children. Yokukansan also improves behavioral and psychological symptoms …

We examined the effect of Yokukansankachimpihange (YKSCH), a form of Yokukansan
containing parts of two herbaceous plants, Citrus Unshiu Peel (Chimpi) and Pinellia Tuber …

Zinc homeostasis in the brain is altered by dietary zinc deficiency, and its alteration may be
associated with the etiology and manifestation of epileptic seizures. In the present study …

On the basis of the evidence of the enhanced susceptibility to kainate-induced seizures in
young rats fed a zinc-deficient diet for 4 weeks, the relationship between zinc release from …

On the basis of the evidence that the excitability of hippocampal glutamatergic
neurotransmitter system is enhanced by dietary zinc deficiency, the response of amygdalar …

Glutamate and zinc is co-released by excitation of hippocampal mossy fibers and both
concentrations are increased in the extracellular compartment. In a novel environment …

γ-Aminobutyric acid (GABA) transporters (GATs) play an important role in inhibitory
neurotransmission by clearing synaptically released GABA and by maintaining low resting …

Approximately 10% of total zinc in the brain exists in synaptic vesicles of glutamatergic
neurons; however, the function of vesicular zinc is poorly understood. The presynaptic action …