All who wander are not lost: the search for homology during homologous recombination

J Hu, JB Crickard - Biochemical Society Transactions, 2024 - portlandpress.com
Homologous recombination (HR) is a template-based DNA double-strand break repair
pathway that functions to maintain genomic integrity. A vital component of the HR reaction is …

Regulation of DNA strand exchange in homologous recombination

JT Holthausen, C Wyman, R Kanaar - DNA repair, 2010 - Elsevier
Homologous recombination, the exchange of DNA strands between homologous DNA
molecules, is involved in repair of many structural diverse DNA lesions. This versatility stems …

An overview of the molecular mechanisms of recombinational DNA repair

SC Kowalczykowski - Cold Spring Harbor Perspectives …, 2015 - cshperspectives.cshlp.org
Recombinational DNA repair is a universal aspect of DNA metabolism and is essential for
genomic integrity. It is a template-directed process that uses a second chromosomal copy …

The RecQ DNA helicases: Jacks-of-all-trades or master-tradesmen?

N Hunter - Cell Research, 2008 - nature.com
Homologous recombination occurs when a damaged chromosome uses an intact
homologous chromosome as a template for its repair. The main steps of recombination are …

How to exchange your partner: Workshop on Recombination Mechanisms and the Maintenance of Genomic Stability

A Aguilera, SJ Boulton - EMBO reports, 2007 - embopress.org
The accurate repair of DNA double-strand breaks (DSBs) is crucial for the maintenance of
genome stability and the prevention of tumours. Homologous recombination (HR) is a …

DNA repair: the search for homology

JE Haber - Bioessays, 2018 - Wiley Online Library
The repair of chromosomal double‐strand breaks (DSBs) by homologous recombination is
essential to maintain genome integrity. The key step in DSB repair is the RecA/Rad51 …

Recombination-mediated genome rearrangements

J Savocco, A Piazza - Current Opinion in Genetics & Development, 2021 - Elsevier
Homologous recombination (HR) is a universal DNA double-strand break (DSB) repair
pathway that uses an intact DNA molecule as a template. Signature HR reactions are …

Dissecting the recombination mediator activity of BRCA2 using biochemical methods

C von Nicolai, Å Ehlén, JS Martinez, A Carreira - Methods in Enzymology, 2018 - Elsevier
Homologous recombination (HR) is an essential pathway to restart stalled replication forks,
repair spontaneous DNA double-strand breaks, and generate genetic diversity. Together …

In vitro assays for DNA pairing and recombination-associated DNA synthesis

J Liu, J Sneeden, WD Heyer - DNA Recombination: Methods and …, 2011 - Springer
Homologous recombination (HR) is a high-fidelity DNA repair pathway that maintains
genome integrity, by repairing double strand breaks (DSBs) and single-stranded DNA …

Structure and function of the double-strand break repair machinery

DS Shin, C Chahwan, JL Huffman, JA Tainer - DNA repair, 2004 - Elsevier
The discovery of the recA gene toward the middle of the 20th century sparked work in
perhaps one of the most biochemically and biophysically intriguing systems of DNA repair …