Obesity, a major risk factor for the development of diabetes mellitus, cardiovascular diseases
and certain types of cancer, arises from a chronic positive energy balance that is often due to …

Leptin is an adipocyte-secreted hormone that inhibits food intake and stimulates energy
expenditure through interactions with neuronal pathways in the brain, particularly pathways …

The rapidly increasing prevalence of obesity confers a huge health burden globally. The
hypothalamus plays a central role in the regulation of energy homeostasis by integrating …

Leptin is an adipocyte-derived hormone, which contributes to the homeostatic regulation of
energy balance and metabolism through humoral and neural pathways. Leptin acts on the …

Because leptin reduces food intake and body weight, the coexistence of elevated leptin
levels with obesity is widely interpreted as evidence of 'leptin resistance.'Indeed, obesity …

Obesity represents a major risk factor for the development of insulin and leptin resistance,
ultimately leading to a pleiotropic spectrum of metabolic alterations. However, resistance to …

The adipose tissue-derived hormone leptin regulates energy balance and neuroendocrine
function. Resistance to the appetite-suppressing effects of leptin is associated with common …

Obesity is a chronic disease that represents one of the most serious global health burdens
associated to an excess of body fat resulting from an imbalance between energy intake and …

Obesity, which has developed into a global epidemic, is a risk factor in most chronic
diseases and some forms of malignancy. The discovery of leptin in 1994 has opened a new …

Leptin, a hormone that is capable of effectively reducing food intake and body weight, was
initially considered for use in the treatment of obesity. However, obese subjects have since …